Effects of aspirin on teratogenic characteristic of alcohol in limb morphoyenesis of mouse embryo
Journal Title: مجله دانشگاه علوم پزشکی شهرکرد - Year 2003, Vol 5, Issue 1
Abstract
Abnormalities caused by alcohol are very extensive and are called fetal alcoholic syndrome (FAS). There are some hypotheses about pathological mechanisms of alcohol. Based on one of the recent hypotheses, alcohol consumption can change maternal and fetal prostaglandin levels. On the other hand aspirin is a strong prostaglandin inhibitor and there are reports showing that simultaneous administration of alcohol and aspirin decreased the limbs and kidney abnormalities in mice offsprings. Others showed that aspirin had no inhibition on alcohol adverse effects. The aim of this study was to determine the effects of aspirin on teratogenic characteristic of alcohol in limb morphogenesis of mouse embryo 135 male and female mice (1 male for 3 females) were randomly divided into 5 groups. After vaginal plaque observation on the 8th day of gestation, controls received nothing while other groups received physiological serum, alcohol, aspirin and a combination of alcohol and aspirin respectively by intraperitoneal injection. On the 18th day of gestation animals were killed by cervical dislocation and embryos were observed for anomalies of the upper and lower limbs. Our results showed that limbs had lower height and weight and more anomalies in alcohol and aspirin group compared to the alcohol alone group. Thus administration of aspirin with alcohol does not decrease the rate of limb abnormalities and factors other than prostaglandin might involve in limb abnormalities.
Authors and Affiliations
Hoshang Rafighdost, Mohamma Akbari, Zahra Heidari
Keywords
Related Articles
- EP ID EP85822
- DOI -
- Views 107
- Downloads 0
تعيين توالي و بررسي مقايسه ايي- بيوانفورماتيكي ژن كد كننده پپتيد شبه (Mesobuthus eupeus) كلروتوكسين از عقرب زرد ايراني
زمينه و هدف: در سال هاي اخير نوروتوكسي ن هاي عقرب از لحاظ خواص دارويي و اثرات فيزيولوژيك مورد مطالع ات زيادي قرار گرفته ان د . يكي از اين توكسين ها كه توجه زيادي را به خود جلب كرده است، كلروتوكسين مي باشد كه هم اكنون د...
Problem–based learning: a new experience in education of pediatric nursing course to nursing students.
Background and aim: Based on the available evidence and experiments, problem-based learning (PBL) is one of the most successful methods in achievement of higher education objectives. In this method, learning is basically...
تعيين اثر طولاني مدت ميدان هاي الكترومغناطيسي بر شاخص هاي خون محيطي كارگران شاغل در كارگاه الكتروليز آلومينيوم شهرستان اراک
چکیده: زمینه و هدف: نظريه بيماري زا بودن ميدان هاي الكترومغناطيسي بر روی ساكنان و كاركنان مجاور اين ميدان ها بخصوص كارسينوژن بودن آنها مورد مطالعات زيادي قرار گرفته است. ولي نتايج آنها قطعيت نيافته و هنوز مناقشات زياد...
بررسي شيوع و نوع خشونت خانگي در زنان باردار مراجعه كننده به مراکز بهداشتی ، درمانی شهرستان شهركرد، سال 1382
چکیده: زمينه و هدف: خشونت خانگي در دوران بارداري تهديد جدي بر سلامت جسمي، رواني و روحي مادر و جنين است و در نهايت تهديد جدي بر سلامت و ساختار جامعه است. هدف از اين تحقيق تعيين شيوع و نوع همسر آزاري در زنان باردار مراج...
Evaluation of WHO’s partogram alert line for prediction of the APGAR score at the first minute after birth
Background and aim: The early diagnosis of abnormal progress of labour and prevention of long term delivery are the main keys to reduce fetal mortality rate due to hypoxia and tissue ischemia. One of the WHO’s proposed m...