Effects of aspirin on teratogenic characteristic of alcohol in limb morphoyenesis of mouse embryo
Journal Title: مجله دانشگاه علوم پزشکی شهرکرد - Year 2003, Vol 5, Issue 1
Abstract
Abnormalities caused by alcohol are very extensive and are called fetal alcoholic syndrome (FAS). There are some hypotheses about pathological mechanisms of alcohol. Based on one of the recent hypotheses, alcohol consumption can change maternal and fetal prostaglandin levels. On the other hand aspirin is a strong prostaglandin inhibitor and there are reports showing that simultaneous administration of alcohol and aspirin decreased the limbs and kidney abnormalities in mice offsprings. Others showed that aspirin had no inhibition on alcohol adverse effects. The aim of this study was to determine the effects of aspirin on teratogenic characteristic of alcohol in limb morphogenesis of mouse embryo 135 male and female mice (1 male for 3 females) were randomly divided into 5 groups. After vaginal plaque observation on the 8th day of gestation, controls received nothing while other groups received physiological serum, alcohol, aspirin and a combination of alcohol and aspirin respectively by intraperitoneal injection. On the 18th day of gestation animals were killed by cervical dislocation and embryos were observed for anomalies of the upper and lower limbs. Our results showed that limbs had lower height and weight and more anomalies in alcohol and aspirin group compared to the alcohol alone group. Thus administration of aspirin with alcohol does not decrease the rate of limb abnormalities and factors other than prostaglandin might involve in limb abnormalities.
Authors and Affiliations
Hoshang Rafighdost, Mohamma Akbari, Zahra Heidari
Keywords
Related Articles
- EP ID EP85822
- DOI -
- Views 101
- Downloads 0
The effect of valerian on hot flash in menopausal women
Background and aims: Menopause is accompanied by a number of complications, which affects the life quality and diminishes feeling of health. The most common of these complications is hot flash. Hormone therapy is commonl...
Low vision in professional drivers, Chaharmahal and Bakhtiari province, 1999
Sufficient vision is essential for driving. However according to the traffic law, changing of driving license and vision test, must be done every ten years, which seems a long time especially for old drivers. The purpose...
The evaluation of tubule formation in breast cancer using fraction of fields showing tubular differentiation (FTD) method and compare it with conventional methods <br /> <br />
Background and aim: Histological grading is one of the most important prognostic factors in breast cancer. So far, there has not been any available method for quantitative estimation of tubular differentiation. Therefore...
Assessment of the knowledge and attitude of the pregnant women who referred to Iran University of Medical Sciences in 2005 toward Islams hygienic instructions during their pregnancy and breast feeding periods
Background and aim: Pregnancy and infancy are as diving profits, which are of the most enjoyable times of women. Islams living doctrine recommends some adwises for pregnant women to have healthy generation with good phys...
The effect of continuous-educational program in interferon therapy on quality of life in patients suffering from Hepatitis B and C.
Background and aim: The most effective therapy for patients with chronic hepatitis C and B is combined therapy with interferon. These treatments, however, cause varying degrees of adverse effects; which may negatively af...