Effects of (-)-epicatechin, a flavonoid on lipid peroxidation and antioxidants in streptozotocin-induced diabetic liver, kidney and heart.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue 5
Abstract
The present study was designed to elucidate the antioxidant effect of (-)-epicatechin in streptozotocin (STZ)-induced diabetes in rats. Intraperitoneal administration of (-)-epicatechin at doses of 15 and 30 mg/kg to diabetic rats for a period of 35 days resulted in a significant decrease in blood glucose, thiobarbituric acid reactive substances and hydroperoxides and a significant increase in the concentration of glutathione and the activities of catalase, superoxide dismutase and glutathione peroxidase. (-)-Epicatechin at a dose of 30 mg/kg was found to be more effective. Administration of insulin to diabetic rats normalized the changes caused by STZ.
Authors and Affiliations
Sabarimuthu Quine, Pamakanthan Raghu
Keywords
Related Articles
- EP ID EP123480
- DOI -
- Views 96
- Downloads 0
Inhibitory effect of antidepressant drugs on contact hypersensitivity reaction.
Background: Contact hypersensitivity (CS) reaction in the skin is T-cell mediated immune reaction which plays a major role in the pathogenesis and chronicity of various inflammatory skin disorders and, like other delayed...
Combinatory effects of PBDEs and 17β-estradiol on MCF-7 cell proliferation and apoptosis.
In the present work, we analyzed whether polybrominated diphenyl ethers (PBDEs) (47, 99, 100 and 209) interfere with the effect of 17β-estradiol on the proliferation and apoptosis of the MCF-7 cell line. MCF-7 cells were...
Responsiveness of 5-HT(2C) receptors in repeatedly diazepam-injected rats: a behavioral and neurochemical study.
The role of 5-hydroxytryptamine (serotonin; 5-HT)(2C) receptors in anxiety and the anxiolytic effects of drugs is well documented. In view of the withdrawal anxiety associated with repeated diazepam intake, the present s...
Different pattern of changes in calcium binding proteins immunoreactivity in the medial prefrontal cortex of rats exposed to stress models of depression.
Reductions in the number and size of neurons in the medial prefrontal cortex (mPFC) have been documented in many post-mortem studies of depressed patients and animals exposed to stress. Here, we examined the effect of ch...
Prenatal stress decreases glycogen synthase kinase-3 phosphorylation in the rat frontal cortex.
It has been postulated that hyperactive glycogen synthase kinase-3 (GSK-3) is an important factor in the pathogenesis of depression, and that this enzyme also contributes to the mechanism of antidepressant drug action. I...