Effects of Essential Oil of SaturejaBachtiarica Bunge in a Rat Model of Reserpine-Induced Depression
Journal Title: Iranian Journal of Medical Sciences - Year 2018, Vol 43, Issue 4
Abstract
Background: Due to the unfavorable side effects of some commonly used chemical drugs, the trend in the public has shifted towards using herbal medicines to treat central nervous system disorders like depression. The present experimental study was designed to evaluate the effect of Marze (Saturejabachtiarica Bunge) essential oil on reserpine-induced depression in rats. Methods: In total, 48 male Wistar rats were randomly divided into 6 groups: 1) control, 2) reserpine, 3-5) reserpine with 50, 75 and 100 mg/kg of Marze essential oil, respectively, and 6) reserpine and fluoxetine. The forced swimming test was used to evaluate the antidepressant activity of the essential oil. Total antioxidant capacity (TAC) and MDA levels of serum and brain were also determined. Results: Reserpine induced a significant increase in the immobility time of rats in the forced swimming test (P=0.02) and treatment with Marze essential oil (50, 100 mg/kg) ameliorated the reserpine induced changes (P=0.04, P=0.03, respectively). Reserpine-induced reduction in brain TCA was improved using Marze essential oil at a dose of 100 mg/kg (P=0.04). Marze essential oil at 100 mg/kg dose significantly decreased the MDA level in the brain tissues of reserpine-treated rats (P=0.04). Conclusion:Marze (Saturejabachtiarica Bunge) essential oil has the ability to prevent depression induced by reserpine probably via its antioxidant activity.
Authors and Affiliations
Maryam Bakhtiarpoor, Mahbubeh Setorki, Mohammad Reza Kaffashian
Keywords
Related Articles
- EP ID EP355519
- DOI -
- Views 78
- Downloads 0
Tubercular Mycobacterial Spindle Cell Pseudotumour: A Case Report
Pseudotumour is a benign inflammatory lesion. Mycobacterial spindle cell pseudotumour (MSP) is a rare pseudotumour. It is a benign proliferation of spindle-shaped histiocytes containing acid-fast mycobacterium, commonly...
High Prevalence of Vitamin D Deficiency among Iranian Population: A Systematic Review and Meta-Analysis
Background: The prevention and correction of vitamin D deficiency requires a precise depiction of the current situation and identification of risk factors in each region. The present study attempted to determine these en...
A New Mutation Causing Severe Infantile-Onset Pompe Disease Responsive to Enzyme Replacement Therapy
Pompe disease (PD), also known as “glycogen storage disease type II (OMIM # 232300)” is a rare autosomal recessive disorder characterized by progressive glycogen accumulation in cellular lysosomes. It ultimately leads to...
An Experimental Study on Spinal Cord µ-Opioid and α2-Adrenergic Receptors mRNA Expression Following Stress-Induced Hyperalgesia in Male Rats
Background: Intense stress can change pain perception and induce hyperalgesia; a phenomenon called stress-induced hyperalgesia (SIH). However, the neurobiological mechanism of this effect remains unclear. The present stu...
Placenta Site Trophoblastic Tumor and Choriocarcinoma from Previous Cesarean Section Scar: Case Reports
Choriocarcinoma and placental site trophoblastic tumor (PSTT) are rare varieties of gestational trophoblastic disease (GTD). PSTT alone constitutes about 1-2% of all trophoblastic tumors, which presents at early reproduc...