Effects of Fluid Resuscitation on Testicular Damage in Severely Burned Rats

Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 12, Issue 10

Abstract

Background: Severe burns cause a wide range of complications that challenge care in the short term and often leaves long term sequelae in survivors. Research evidence suggests that burns can affect testosterone secretion, and impair spermatogenesis and fertility. This study was designed to investigate the effects of fluid resuscitation on spermatogenesis and histology of the testes after major burns. Methodology: Third degree burns was induced on dorsal skin of 3 groups of male Wistar rats. Intra-venous resuscitation fluid was administered, ½ h and 3 h post-burn in the first 2 groups. A fourth group had sham burn only and served as negative control. After 8 weeks the animals were sacrificed evaluated for sperm parameters, testicular histology and assays of oxidative status. Main Findings: Fluid administration did not cause significant difference in sperm parameters or in levels of markers of oxidative stress among the animals with burn injury. Mean sperm density in groups 1 and 2 which had fluid treatment were 57.00±11.99 and 56.33±9.49 respectively compared to 49.00±6.24 in the untreated group 3 (p=0.921 and 0.947). However total counts were significantly lower in all burned groups than in the sham burn group. Fluid treatment produced a time-dependent relief from the histological disruptions associated with the burns. Tubules with germ cell loss were fewer in the fluid treated groups than in the untreated one. Conclusion: Fluid treatment in burn patients may not protect them from suppression of testicular function. Fertility damage in severe burns may involve mechanisms that do not depend on intravascular volumes and pressures.

Authors and Affiliations

P. I. Jewo, I. O. Fadeyibi, A. B. Ojekale, J. A. Oguntola

Keywords

Related Articles

Comparison of Ultrasound and Scheimpflug Methods for Central Corneal Thickness

Aim: The central corneal thickness (CCT) of healthy individuals was measured with an ultrasonic pachymeter (UP) and the Scheimpflug imaging system (SIS) and the results were compared to evaluate the agreement between the...

Treatment for Gynaecomastia in Men. Experience with the Inferior Periareolar Incision in a Single Third Level Medical Facility

Background: Gynaecomastia is defined as an enlargement of the mammary gland in men. Objective: To evaluate Aesthetic Results of Subdermal Mastectomy by means of Inferior Periareolar Incision. Materials and Methods: Des...

Insulinomimetic, Antihyperlipidemic and Antioxidative Properties of Azadirachta indica. Possible Mechanism of Action

Currently available synthetic drugs for management of diabetes mellitus have been reported to cause side effects, hence searches for safer, readily available and cheaper sources among medicinal plants. One hundred and th...

Isolated Unilateral Adduction Paresis of the Right Eye Due to a Contusion in the Subnucleus of Oculomotor Nerve

In this report we present a 45 year old man with horizontal diplopia following minor head trauma. Neurological examination was normal except for unilateral adduction paresis of the right eye. Brain magnetic resonance ima...

Primary Intracerebral Haematoma Evacuation: A Case Report

Spontaneous intracerebral hemorrhage is one of the most devastating types of stroke, leading to disability and high mortality rate. Besides blood pressure reduction and intensive medical and surgical treatment, immediate...

Download PDF file
  • EP ID EP340457
  • DOI 10.9734/BJMMR/2016/21987
  • Views 106
  • Downloads 0

How To Cite

P. I. Jewo, I. O. Fadeyibi, A. B. Ojekale, J. A. Oguntola (2016). Effects of Fluid Resuscitation on Testicular Damage in Severely Burned Rats. Journal of Advances in Medicine and Medical Research, 12(10), 1-8. https://europub.co.uk/articles/-A-340457