Effects of Fluid Resuscitation on Testicular Damage in Severely Burned Rats

Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 12, Issue 10

Abstract

Background: Severe burns cause a wide range of complications that challenge care in the short term and often leaves long term sequelae in survivors. Research evidence suggests that burns can affect testosterone secretion, and impair spermatogenesis and fertility. This study was designed to investigate the effects of fluid resuscitation on spermatogenesis and histology of the testes after major burns. Methodology: Third degree burns was induced on dorsal skin of 3 groups of male Wistar rats. Intra-venous resuscitation fluid was administered, ½ h and 3 h post-burn in the first 2 groups. A fourth group had sham burn only and served as negative control. After 8 weeks the animals were sacrificed evaluated for sperm parameters, testicular histology and assays of oxidative status. Main Findings: Fluid administration did not cause significant difference in sperm parameters or in levels of markers of oxidative stress among the animals with burn injury. Mean sperm density in groups 1 and 2 which had fluid treatment were 57.00±11.99 and 56.33±9.49 respectively compared to 49.00±6.24 in the untreated group 3 (p=0.921 and 0.947). However total counts were significantly lower in all burned groups than in the sham burn group. Fluid treatment produced a time-dependent relief from the histological disruptions associated with the burns. Tubules with germ cell loss were fewer in the fluid treated groups than in the untreated one. Conclusion: Fluid treatment in burn patients may not protect them from suppression of testicular function. Fertility damage in severe burns may involve mechanisms that do not depend on intravascular volumes and pressures.

Authors and Affiliations

P. I. Jewo, I. O. Fadeyibi, A. B. Ojekale, J. A. Oguntola

Keywords

Related Articles

Assisted Reproduction and Cross-Border Maternal Surrogacy Regulations in Selected Nations

Aims: To ascertain the laws and policies of selected high income countries, with respect to the disposition of their citizens seeking assisted reproductive technologies (ARTs) internationally. Study Design: Literature re...

Association between Intraoperative and Post-Anesthetic Care Unit Respiratory Events among 12,641 Children in Southern Thailand

Aims: The association between intraoperative respiratory events (IRE) and post-anesthetic care unit respiratory events (PARE) in children as well as the risk factors for PARE have not been described. The objectives of th...

An Evaluation of QuantiFERON-TB Gold in-Tube and Immunological Tests for TB Diagnosis in Iraqi Patients

Aims: Tuberculosis is an infectious disease caused by the bacillus Mycobacterium tuberculosis and other related species. It typically affects the lungs (pulmonary TB) but can affect other sites (extra-pulmonary TB). A p...

Lipedema: A Clinical Challenge-revisited

Lipedema is a disfiguring disorder with abnormal and progressive deposition of adipose tissue in the hips and lower extremities almost exclusively occurring in women. There is a hereditary tendency and a substantial vari...

The Current Robotic da Vinci System has Limitations for Colorectal Surgical Procedures

Since the introduction of the robotic da Vinci Surgical System, several advantages have been demonstrated in all surgical specialties, particularly in pelvic surgery. However, the current system still has several limitat...

Download PDF file
  • EP ID EP340457
  • DOI 10.9734/BJMMR/2016/21987
  • Views 104
  • Downloads 0

How To Cite

P. I. Jewo, I. O. Fadeyibi, A. B. Ojekale, J. A. Oguntola (2016). Effects of Fluid Resuscitation on Testicular Damage in Severely Burned Rats. Journal of Advances in Medicine and Medical Research, 12(10), 1-8. https://europub.co.uk/articles/-A-340457