Effects of Fluid Resuscitation on Testicular Damage in Severely Burned Rats
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 12, Issue 10
Abstract
Background: Severe burns cause a wide range of complications that challenge care in the short term and often leaves long term sequelae in survivors. Research evidence suggests that burns can affect testosterone secretion, and impair spermatogenesis and fertility. This study was designed to investigate the effects of fluid resuscitation on spermatogenesis and histology of the testes after major burns. Methodology: Third degree burns was induced on dorsal skin of 3 groups of male Wistar rats. Intra-venous resuscitation fluid was administered, ½ h and 3 h post-burn in the first 2 groups. A fourth group had sham burn only and served as negative control. After 8 weeks the animals were sacrificed evaluated for sperm parameters, testicular histology and assays of oxidative status. Main Findings: Fluid administration did not cause significant difference in sperm parameters or in levels of markers of oxidative stress among the animals with burn injury. Mean sperm density in groups 1 and 2 which had fluid treatment were 57.00±11.99 and 56.33±9.49 respectively compared to 49.00±6.24 in the untreated group 3 (p=0.921 and 0.947). However total counts were significantly lower in all burned groups than in the sham burn group. Fluid treatment produced a time-dependent relief from the histological disruptions associated with the burns. Tubules with germ cell loss were fewer in the fluid treated groups than in the untreated one. Conclusion: Fluid treatment in burn patients may not protect them from suppression of testicular function. Fertility damage in severe burns may involve mechanisms that do not depend on intravascular volumes and pressures.
Authors and Affiliations
P. I. Jewo, I. O. Fadeyibi, A. B. Ojekale, J. A. Oguntola
The Prevalence and the Predictors of Complementary and Alternative Medicine among Children on Highly Active Antiretroviral Therapy in Makurdi, Nigeria
Aims: To determine the prevalence, the pattern of usage and the predictors of complementary and alternative medicine (CAM) among children on highly active antiretroviral therapy (HAART). Study Design: Prospective, Cross...
Increases of Cardiometabolic Risk in Young Adults. Impact of Exercise Reductions during the College Years
Aims: The transition from school to university, traineeship or job especially along with moving away from home may lead to unhealthy lifestyle changes in young adults. Thus, we determined the effect of exercise changes d...
Colon Obstruction and Gradual Regression of Giant Pseudopolyps in Inflammatory Bowel Disease
Inflammatory pseudopolyps associated with inflammatory bowel disease occur on inflamed colon mucosa due to the regeneration and healing of ulcerated epithelium. They are classified as giant when they are over 1.5-cm in d...
The Effect of Acute Co-administration of Fansidar® with Vitamin C on Some Serum Electrolytes and Body Weight Changes in Male and Female Wistar Albino Rats
Aims: To investigate the effect of fansidar® and vitamin C co-administration on serum electrolyte and body weight indices of Wistar albino rats. Place and Duration of Study: Department of Medical Biochemistry, Cross Rive...
Prevalence of Musculoskeletal Pain and Body-Chair Mismatch among Junior High School Students in Ghana: A Risk Factor for the Young
Aim: To determine the prevalence of musculoskeletal pain and body-chair mismatch among Junior High School (JHS) students in Ghana. Study Design: This was a cross sectional study. Place and Duration of Study: The study...