Effects of flunixin meglumine on experimental tendon wound healing: A histopathological and mechanical study in rabbits
Journal Title: Veterinary Research Forum - Year 2013, Vol 4, Issue 4
Abstract
Tendons are frequently targets of injury in sports and work. Whether nonsteroidal anti-inflammatory drugs (NSAIDs) have beneficial effects on tendon healing is still a matter of debate. This study was conducted to evaluate effects of flunixin meglumine (FM) on tendon healing after experimentally induced acute trauma. Twenty eight adult male New Zealand White rabbits were subjected to complete transection of deep digital flexor tendons followed by suture placement. Treatment group received intramuscular injection of FM for three days, and controls received placebo. Subsequently, cast immobilization was continued for two weeks. Animals were sacrificed four weeks after surgery and tissue samples were taken. The histological evaluations revealed improved structural characteristics of neotendon formation including fibrillar linearity, fibrillar continuity and neovascularization in treatment group compared to those of controls (p < 0.05). However, no significant differences were found between two groups in terms of epitenon thickness (p > 0.05). Mechanical evaluation revealed significant increase in load-related material properties including ultimate load, yield load, energy absorption and ultimate stress in treatment group compared to those of control group (p < 0.05). However, no statistically significant differences in terms of stiffness and ultimate strain were found (p > 0.05). The present study showed that intramuscular injection of FM resulted in improved structural and mechanical properties of tendon repairs and it could be an effective treatment for acute tendon injuries like severance and laceration.
Authors and Affiliations
Mehdi Behfar, Rahim Hobbenaghi, Farshid Sarrafzadeh-Rezaei Sarrafzadeh-Rezaei
Keywords
Related Articles
- EP ID EP109922
- DOI -
- Views 103
- Downloads 0
The response of ducks to V4 Newcastle disease virus and its transmission to contact ducks and domestic chickens
Experimental infection of Muscovy ducks with V4 strain of Newcastle disease virus was undertaken to determine the response of the ducks to the virus and the possibility of virus transmission to ducks and chickens in vill...
Effects of ginger extract on smooth muscle activity of sheep reticulum and rumen
Reticulorumen hypomotility leads to the impaired physiologic functions of the digestive tract. Prokineticaction of ginger has been demonstrated in the laboratory animals and human. The aim of this study was to...
Physicochemical and antioxidative characteristics of Iranian pomegranate (Punica granatum L. cv. Rabbab-e-Neyriz) juice and comparison of its antioxidative activity with Zataria multiflora Boiss essential oil
Pomegranate juice (PJ) and its products are directly used in foods due to their pleasant taste and palatability as well as preservative effects. In spite of useful effects of essential oils such as zataria multiflora Boi...
Histomorphometric study of on blood cells in male adult ostrich
In order to perform a histomorphometric study of blood cells in male adult ostrich, blood samples were obtained from jugular vein of 10 clinically healthy male adult ostriches (2 - 3 years old). The slides were stained w...
Sero-prevalence of bluetongue disease in sheep in west and northwest provinces of Iran
The objective of this study was to describe the seroprevalence rates of bluetongue virus (BTV) in sheep in west and northwest provinces of Iran. Bluetongue virus, an economically important orbivirus of the Reoviridae fam...