Effects of green tea catechins on spatial learning abilities of wistar rats
Journal Title: Journal of Pharmaceutical and Biological Sciences - Year 2018, Vol 6, Issue 2
Abstract
Introduction Green tea has drawn much attention because of the increase in the number of studies describing its potential health benefits which are attributed to Epigallocatechin3gallate EGCG Recent studies have also shown that in addition to antioxidant effects green tea catechins modulates cell cycle signaling generates non amylodogenic APP enhances activity in dorsolateral prefrontal cortex etcMaterials and Method The study was done in 18 male albino Wistar rats and divided in three groups of six The spatial learning ability of rats were assessed by their behavior in 8 arm radial maze Results Statistical analysis was done using SPSS version 22 and data analyzed using Independence sample T test Paired T test and ANOVA The maze study showed an improvement in spatial learning ability of rats after green tea consumption in group1 and 2 as the time taken by the animal to complete the maze was found to be decreased Conclusion Administration of green tea catechins improves the spatial learning abilities of rats with an improved performance in radial maze tasks The neuroprotective effect of green tea catechins may be due to their antioxidant property and hence can be used an effective tool in delaying cognitive impairment in elderlyKeywords Green tea EGCG Radial maze Cognition
Authors and Affiliations
Ambili Gopi Nair, Shilpa AV, Biju Bahuleyan, K Rajankutty
Keywords
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- EP ID EP512455
- DOI 10.18231/2320-1924.2018.0009
- Views 102
- Downloads 0
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