EFFECTS OF HYPERGLYCEMIA ON RENAL FUNCTION IN TYPE-2 DIABETES MELLITUS PATIENTS
Journal Title: International Journal of Basic and Applied Physiology - Year 2015, Vol 4, Issue 1
Abstract
Background: Diabetes mellitus is one of the most common metabolic abnormality in the world. Type-2 diabetes (NIDDM) is the commonest form of diabetes constituting 90% of the diabetic population in any country. Diabetic nephropathy has become leading cause of end-stage kidney disease worldwide. There is progressive change in the structure and function of the kidney. Death rates and rate of renal function decline increases as the disease progresses. Objectives: To evaluate the effect of hyperglycemia on renal function in type-2 DM patients and to compare it with those of non-diabetic healthy subjects. Methods: 50 type-2 DM patients of both sexes having DM for more than 1 year between 40-60 years attending medicine OPD & 50 nondiabetics of both sexes of same age without hypertension, any renal diseases like stones, gestational DM, endocrine disorders, alcohol abuse were recruited. The renal function tests, Fasting Blood Sugar, S.creatinine, Blood urea were performed and compared by using suitable statistical methods (unpaired student t-test, p value and pearson correlation coefficient). Result: Diabetics have high FBS, S.creatinine and Blood urea as compare to nondiabetics. Conclusion: Increase in Blood sugar had direct relationship with Serum creatinine and Blood urea in type-2 DM patients.
Authors and Affiliations
Sharlin B. Christian, Sudha Parmar, R. S. Trivedi
Keywords
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