Effects of hyrdroethanolic leaf extract of Pseudospondias microcarpa (A. Rich.) Engl. (Anacardiaceae) on the central nervous system in mice
Journal Title: The Journal of Phytopharmacology - Year 2014, Vol 3, Issue 6
Abstract
Pseudospondias microcarpa (Anacardiaceae), the African grape tree, is used for various CNS disorders. The neuropharmacological activities of the hydroethanolic leaf extract of Pseudospondias microcarpa (PME) were screened in mice. In this study, the central nervous system (CNS) activity was tested in various animal models including Irwin test, pentobarbitone-induced sleeping time, spontaneous motor activity, rotarod test, pentylenetetrazole-induced convulsions and tail immersion test. The extract produced sedation and analgesia in the Irwin test with an LD50 above 3000 mg kg-1. PME potentiated pentobarbitone sleeping time and induced hepatic enzymes. It however, showed no effect on locomotor activity or motor coordination. Furthermore, the extract blocked convulsions induced by PTZ and showed analgesic activity in the tail withdrawal test. The present investigation suggests that PME may act as a sedative with analgesic and anticonvulsant activity, and thus supporting its use as a sedative and for the relief of various nervous system disorders.
Authors and Affiliations
Donatus Wewura Adongo, Priscilla Kolibea Mante, Eric Woode, Elvis Ofori Ameyaw, Kennedy Kwami Edem Kukuia
Keywords
Related Articles
- EP ID EP49593
- DOI -
- Views 262
- Downloads 0
Evaluation of psychopharmacological activity of ethyl acetate extract of Sarcostemma acidum (Roxb).Voigt
Herbal medicines are gaining growing interest because of their cost- effective, eco- friendly attributes and true relief from disease condition. Sarcostemma acidum was documented in many folklore practices for various...
In vitro and in vivo evaluation of antibacterial activity of Bridelia ferruginea extracts on some clinical isolates
The ethanol extracts of root, bark and leaf of Bridelia ferruginea was investigated for antibacterial activity against clinical isolate of Staphylococcus aureus and Escherichia coli. The extracts had significant antiba...
Inhibition of Dehydrogenase Activity in Pathogenic Bacteria Isolates by Aqueous Extract of Curcuma Longa (Turmeric) Rhizome
Inhibition of dehydrogenase activity in pathogenic Gram – positive and Gram – negative microorganism exposed to ethanol extract of curcuma longa was used as an index for assessment of its antibacterial activity. Assay o...
Experimental study on Operculina turpethum in STZ induced diabetic neuropathy, neurodegeneration and cardiovascular complications
Neuropathy and Cardiac complications are the most common trouble in diabetes mellitus with progressive damage due to complex pathogenesis. Many conventional pharmacological agents were withdrawn from clinical studies e...
Toxicological assessment of the methanolic leaf extract of Bridelia ferrugelia
This study evaluated the acute and subacute toxicity effects of Bridelia ferrugelia leaf extract. Observation of the acute group showed that LD50 of the extract is greater than 2000 mg/kg. The subacute investigation was...