Effects of Intra-Articular Platelet-Rich Plasma Administration in Temporomandibular Joint Arthritis: An Experimental Study
Journal Title: Meandros Medical and Dental Journal - Year 2018, Vol 19, Issue 3
Abstract
Objective: Osteoarthritis is defined as a disease that begins with focal and progressive destruction in articular cartilage with biomechanical, biochemical, inflammatory and immunologic reactions and may cause pathologic changes in the subchondral bone and joints. The platelet-rich plasma accelerates wound and bone healing in clinical trials; decreases swelling, pain, infection and scarring; and controls bleeding. In this study, we studied the effect of intraarticular thrombocyte-rich plasma administration in the model of temporomandibular osteoarthritis induced by monosodium iodoacetate (MAI) injection. Materials and Methods: Forty-five Wistar male rats were used in the study. The rats were divided into 3 groups, each containing eight animals. In the first group, only serum physiologic injections were performed to the temporomandibular joints and identified as the control group. In the second group, arthritis model was created by injecting MAI to the temporomandibular joint. Third group was the study group intraarticular platelet rich plasma injections were performed 4 weeks after monosodium iodoacetate injections. Results: When cartilage thicknesses were evaluated, there was a significant decrease in group 3 arthritis when compared with other groups. In the study group, cartilage thickness was not significantly different from control groups, but statistically significant improvement was observed when compared to monosodium idoacetate group. Although subchondral cyst formations were also observed in the study group a statistically significant difference was observed between the arthritis group. Conclusion: We believe that our study results support, and enlightens therapeutic effects of platelet rich plasma on temporomandibular joint arthritis.
Authors and Affiliations
Heval Selman Özkan, Saime İrkören, Huray Karaca, Taha Deniz Yıldırım, Kadir Çiçek, Canten Tataroğlu
Keywords
Related Articles
- EP ID EP399339
- DOI 10.4274/meandros.29484
- Views 116
- Downloads 0
Oral Precancerous Lesions in Childhood: Attention to the Pediatricians and Pediatric Dentists
Precancerous lesions of oral mucosa, known as premalignant disorders, have greater malignant transform risk concerning dysplastic changes, carcinoma in situ or oral cancers. Oral lichen planus, oral leukoplakia, oral ery...
Rational Use of Drugs Among Inpatients and Its Association with Health Literacy
Objective: Rational use of drugs (RUD) plays a vital role in the success of the treatment process. Considering that use of medicines is also related with decision making mechanisms of individuals, RUD and health literacy...
Dental Anxiety in Relationship to Demographic Status and Periodontal Health in Adults
Objective: Dental anxiety is a major complication for many patients and practitioners. Dental fear often results in poor oral health in regard to poor cooperation. The aim of the present study was to determine the dental...
Vitamin D Level and Infertility
Infertility is one of the major health problems of our time. In fact, infertility is caused by many factors. Among these factors the effect of vitamin D levels of infertility are overlooked. The prevalence of vitamin D d...
An Experience of General Anesthesia in a Case of Parkinson's Disease
Parkinson's disease (PD) is a neurodegenerative disease which is resulted from loss of dopaminergic neurones in the substantia nigra of the basal ganglia and is a characterized by the triad of resting tremor, muscle rigi...