Effects of Intravesical Mitomycin and Distilled Water on Recurrence After TUR-TM in Ta, T1 Tumors
Journal Title: Journal of Clinical and Analytical Medicine - Year 2011, Vol 2, Issue 3
Abstract
Aim The elimination of floating tumor cells inside bladder during and after transurethral resection of tumor (TUR-Tm) due to the cytolytic effects of distilled water has been demonstrated. In this study, our aim is to compare the effects of diluted mitomycin-C (MMC) with distilled water and/or saline with distilled water alone on early recurrence risk. Material and Methods 43 patients with Ta-T1 stage transitional cell carcinoma (TCC) have been investigated in 4 groups. MMC 40mg diluted with distilled water and/or saline was applied to the first two groups. Distilled water and saline alone were administered to the other two groups. All instillations were done intravesically within 2-4 hours after resection and kept inside for 2 hours. Patients were controlled in 3, 6, 9 and 12th months by cystoscopic evaluation. Results No differences were obtained among patients in the study groups in terms of tumor characteristics. Recurrence was observed only in 5 patients (11.6%) during 12 month follow-up period. Although, there was no recurrence in group I (MMC+ saline) and III (distilled water), recurrence was detected in group IV (saline) (3 patients, 27.3%) at 3th month and in group II (MMC+ distilled water) (2 patients, 20%) at 6th month (p=0.102). Conclusions According to our preliminary results there were no significant differences in terms of development of recurrence among treatment groups. Clinical clues have been obtained about non-chemotherapeutic agents, such as distilled water, might be effective in preventing recurrence of the tumor. Supporting our data with more number of patients and longer follow-up was concluded for further researches.
Authors and Affiliations
Can Ali Tatar, Nasır Yılmaz, Ömer Gökhan Doluoğlu, Öztuğ Adsan
Keywords
Related Articles
- EP ID EP124840
- DOI 10.4328/JCAM.330
- Views 93
- Downloads 0
Thoracic Esophageal Perforation After Blunt Trauma in a Child: A Delayed Diagnosis and Surgical Management
Esophageal rupture due to external blunt trauma is extremely rare in children. A-13-year old boy was admitted to emergency room with shortness of breath and abdominal pain. His history revealed fall down from 3 metres he...
Pure Motor Aphasia Developed After Cerebral Vasculitis due to Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a complex multisystem disease that may involve the central and peripheral nervous systems. Common clinical findings include seizures, depression, psychosis, aseptic meningitis, hea...
Ksifodini ile Kendini Gösteren Talasemi Minör
Ksifodini, ksifoid kemik veya ksifosternal bileşkeye bağlı olarak ortaya çıkan üst abdominal ağrı, göğüs ağrısı, boğaz, baş ve kola yayılabilen ağrı ile karakterize bir grup semptomu içeren nadir bir sendromu tarif ede...
Evaluation of the Burn Patients Presenting to Emergency Clinic of a Education Hospital
Aim: Burn is a significant cause of morbidity and mortality in all age groups. Its treatment requires a multidisciplinary approach. In this study we aimed to evaluate burn cases and discuss the relevant literature. M...
Rat Plazma Örneklerinde Yüksek Basınçlı Sıvı Kromatografisi (HPLC) ile Yeni Bir Monopiridinyum Oksim Olan TS-131’in Ölçümü
Amaç TS-131, mevcut ticari oksimlere potansiyel bir alternatif olarak geliştirilmiş bir monopiridinyum aldoksim tipi kolinesteraz reaktivatörüdür. Rat plazma örneklerinde TS-131’in konsantrasyonlarının ölçümü için; sensi...