Effects of Lactic Acid produced by lactic acid bacteria on Prodigiosin Production from Streptomyces coelicolor
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 9
Abstract
Background: Several approaches were carried out ranging from improving nutrient sources to metabolic engineering of Streptomyces coelicolor or co-cultivation with cell-free supernatant from lactic acid bacteria. Methods: Lactic acid isolated from Leuconostoc mesenteroides and Lactobacillus plantarum was detected on thin layer chromatography and quantitated by spectrophotometry and then, added into medium that was used to check for prodigiosin production ability of Streptomyces coelicolor. The intracellular and extracellular prodigiosin amounts were measured by spectrophotometry. Results: Approximately 0.109 g/mL - 0.117 g/mL of lactic acid produced by Lactobacillus plantarum and Leuconostoc mesenteroides (106 CFU/mL) was obtained. The production of intracellular prodigiosin treated with different extracts from lactic acid bacteria after 6 days of incubation was less than nine fold when compared with the culture without lactic acid. The production of extracellular prodigiosin treated with different extracts from L. mesenteroides lactic acid bacteria after 6 days of incubation was higher than L. plantarum, but less than the culture without lactic acid. Conclusion: There was inhibition effect of lactic acid produced by Lactobacillus plantarum and Leuconostoc mesenteroides on intracellular and extracellular prodigiosin.
Authors and Affiliations
Tu Nguyen
Keywords
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