Effects of laparoscopic surgery combined with hyperthermic intraperitoneal chemotherapy on postoperative coagulation indicators in patients with colorectal cancer
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 9
Abstract
Objective To observe the changes of coagulation function in patients with colorectal cancer (CRC) after laparoscopic surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC). Methods Sixty patients with CRC admitted to The People's Hospital of Kaizhou District, CQ from January to October 2023 were selected as the study subjects and randomly divided into study group and control group, with 30 cases in each group. The control group underwent laparoscopic surgery, while the study group underwent laparoscopic surgery combined with HIPEC (fluorouracil). The surgical conditions and changes in perioperative coagulation function indicators were observed and compared between two groups. Results There was no statistically significant difference between the study group and the control group in intraoperative blood loss ［（84.33±40.66）mL vs （100.33±52.82）mL］, surgical time ［（174.77±31.29）min vs （167.67±28.61）min］, anal exhaust time ［（3.17±0.79）d vs （3.03±0.81）d］, and postoperative hospital stay ［（14.23±3.76）d vs （14.70±5.34）d］ (P＞0.05). The levels of prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), and D-dimer (D-D) in the two groups showed significant fluctuations over time (P＜0.05), while there was no significant difference in the above indicators between the two groups (P＞0.05). There was no statistically significant difference in the total incidence of postoperative complications (20.00% vs 13.33%, χ2=0.481, P=0.488) such as abdominal bleeding, deep vein thrombosis, intestinal obstruction, and anastomotic fistula between the two groups. Conclusion Although laparoscopic surgery leads to enhanced coagulation function and hypercoagulable blood in patients with CRC, the combination of postoperative HIPEC does not increase the risk of postoperative deep vein thrombosis, therefore, HIPEC technology is still safe and reliable.
Authors and Affiliations
WANG Hongbing, WU Wan, PU Zhizhong, ZHANG Lihua, WANG Yubin, XU Hao
Keywords
Related Articles
- EP ID EP745453
- DOI 10.13429/j.cnki.cjcr.2024.09.007
- Views 26
- Downloads 0
Correlation between cardiometabolic index and stroke in middle-aged and older adults
Objective To explore the relationship between cardiac metabolic index (CMI) and stroke in middle-aged and elderly individuals based on a large sample cohort study. Methods Data were obtained from the China Health and Ret...
Research progress of esketamine and postoperative delirium
Postoperative delirium (POD) is a common complication in elderly patients after surgery, significantly affecting prognosis and increasing mortality rates. The underlying mechanisms of POD remain unclear, with diverse ris...
Research progress on the pathogenesis and treatment of cervical spondylotic myelopathy
Cervical spondylotic myelopathy (CSM) is the most serious subtype of cervical spondylosis, which is the main cause of spinal cord dysfunction in middle-aged and elderly people, and the pathogenesis of this CSM is complex...
Research progress and treatment status of non-ischemic cardiomyopathy
Cardiomyopathy is a heart disease clinically characterized by enlargement of the heart, arrhythmia and heart failure alone or simultaneously. Ischemic cardiomyopathy is usually caused by coronary atherosclerotic lesions,...
Effects of unicondylar and total knee arthroplasty on knee osteoarthritis
<b>Objective</b> To compare the therapeutic effects of unicondylar knee arthroplasty (UKA) and total knee arthroplasty (TKA) on knee osteoarthritis (KOA) to provide references for the clinical selection of the best surg...