Effects of melatonin and agomelatine on doxorubicin induced anxiety and depression-like behaviors in rats
Journal Title: Medical Science and Discovery - Year 2018, Vol 5, Issue 7
Abstract
Objective: Doxorubicin (DOX) is a chemotherapeutic agent used to treat several cancer types; however, it exhibits severe side effects in the nervous system which DOX treatment evoked neurobehavioral alterations such as anxiety and depressive-like behavior. We investigated the use of melatonin and agomelatine to prevent neurobehavioral alterations caused by DOX. Material and Methods: Forty-nine Wistar albino rats were randomly divided into 7 groups, namely control (CON, n=7), doxorubicin (DOX, n=7), melatonin (MEL, n=7), agomelatine (AGO, n=7), melatonin + doxorubicin (MEL + DOX, n=7), agomelatine + doxorubicin (AGO + DOX, n=7) melatonin + agomelatine + doxorubicin (MEL + AGO + DOX, n=7) groups. Doxorubicin (18 mg/kg) was injected intraperitoneally (i.p) on the 5th, 6th, 7th day of the study. Animals were treated with melatonin (40 mg/kg/i.p), agomelatine (40 mg/kg/i.p), melatonin (40 mg/kg/i.p) + agomelatine (40 mg/kg/i.p), for 7 days and then doxorubicin (18 mg/kg/i.p) was injected on the 5th, 6th, 7th day. On the 8th day of the experiment, all animal evaluated open field test (OFT) and forced swim test (FST) respectively. Results: The only DOX-treated rats exhibited the reduced exploration, grooming, and locomotor activity in the open field test and increased immobility time, reduced swimming time. Our data showed that the rats treated with DOX exhibited anxiety and depressive-like behavior. Melatonin and agomelatine treatment reduced all the parameters of DOX-induced anxiety and depressive-like behavior in rats. Conclusions: Melatonin and agomelatine have a protective effect of against DOX-induced neurobehavioral alterations in rats.
Authors and Affiliations
Hatice Aygun, Serdar Savas Gul
Keywords
Related Articles
- EP ID EP520684
- DOI 10.17546/msd.433289
- Views 63
- Downloads 0
The effects of application of 0.5% levobupivacaine together with 5 mg dexamethasone for infra-clavicular block in surgical treatment of forearm fractures
Objective: We aimed to investigate the effects of adding 5mg dexamethasone to 0.5% levobupivacaine on postoperative analgesia after US-guided infra-clavicular block. Methods: This prospective study was perf...
Is ultrasound-guided transversus abdominis plane block in providing analgesia in pediatric cases safe and efficient?: A retrospective study
Objective: The use of high or insufficient doses of analgesics in pediatric cases unfavorably affects the patient’s health in the postoperative period. Ultrasound-guided transversus abdominis plane (TAP) bloc...
Approach to hydatid cyst rupture patient who administered with anaphylactic shock
Hydatid cyst is a parasitic disease, which can involve liver, lungs, spleen, kidneys, orbita, heart, brain and bone. In case of rupture it can cause anaphylactic reactions, shock and cardiovascular collapse. Cyst hydatid...
Thoracoabdominal asynchrony correlates with peripheral vascular resistance changes in a cohort of obese children.
Objective: The purpose of this study was to assess the relationship between the thoracoabdominal asynchrony (phase angle), as an index of inspiratory airflow resistance, pulse transit time arousal index (PTT A...
PERIOPERATIVE CONTROL OF BLOOD GLUCOSE
This review mainly focuses on the management of type 2 diabetes in the preoperative setting with a special emphasis on intraoperative glycemic control. Some patients learn their diagnosis of diabetes just prior to the su...