Effects of Melatonin at Different Doses on Experimental Epilepsy Model Induced By Pentylenetetrazole
Journal Title: Meandros Medical and Dental Journal - Year 2021, Vol 22, Issue 2
Abstract
Objective: This study aimed to evaluate the effect of melatonin (MEL) treatment on rats with experimental epilepsy induced by pentylenetetrazole (PTZ). Changes in the control, epilepsy and two treatment groups (25 mg/kg and 100 mg/kg) were monitored as intragroup and intergroup changes. Materials and Methods: Forty male Wistar albino rats (12-14 weeks old) were divided into control, PTZ, MEL25 and MEL100 groups, with 10 rats in each group. Only solvent was injected in the control group, and PTZ at a dose of 35 mg/kg was administered intraperitoneal 12 times in a total of 23 days in the PTZ group. MEL25 and 100 mg/kg were administered in the MEL25 and MEL100 groups, respectively. Parameters tested during and after the experiment were behavioural tests (elevated plus maze), biochemical tests in brain tissue [after decapitation; malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), total antioxidant status (TAS) and total oxidant status (TOS)] and epileptic seizure severity scale scores (every injection day). Results:Significant differences were observed among the epilepsy, control and treatment groups, except for the hiding times, seizure scores and biochemical tests (p<0.05). As a result of biochemical tests applied to the homogenised brain tissue after decapitation, dose-dependent results were found to be related to the different doses of MEL applied in MDA, CAT, SOD, TAS and TOS levels (p<0.05). Conclusion: In this study, MEL showed a protective and healing role against physiological changes caused by experimental epilepsy, through its capacity to reduce oxidative damage and increase antioxidant potency.
Authors and Affiliations
Ferhat Şirinyıldız, Rauf Onur Ek
Keywords
Related Articles
- EP ID EP694417
- DOI 10.4274/meandros.galenos.2021.49358
- Views 131
- Downloads 0
Arthroscopic Decompression in Subacromial Impingement Syndrome: An Overview of Our Outcomes
Objective: Subacromial Impingement syndrome (SIS) is a common cause of shoulder pain due to compression of rotator cuff muscles. We aimed to compare preoperative and postoperative functional and radiological features aft...
Anaphylaxis After the First Dose of Lansoprazole: A Case Report
Drug-induced anaphylaxis is a life-threatening condition that is rapid in onset and defined as a serious allergic or hypersensitivity reaction. Proton pump inhibitors are widely used for the treatment of acid-related dis...
Repair of a Partial Anomalous Pulmonary Venous Connection After Mitral Valve Replacement: A Case Report
Partial anomalous pulmonary venous connection (PAPVC) is a rare congenital disorder with an incidence 0.5% of all congenital cardiac defects. Usually seen with congenital cardiac defects such as sinus venosus type intera...
A Reason of Facial Diplegia: Guillain- Barré Syndrome
Guillain-Barré syndrome (GBS), an acute demyelinating inflammatory poliradiculopathy, is characterised by rapidly progressive, symmetrical, ascending weakness and areflexia. The disease usually occurs after 1-3 weeks of...
Assessment of the Effects of Light and Sound Impulses on the Electrical Potential of the Eye and Ocular Muscles
Objective: The aim of this study is to determine the effects of visible light on the electrical potential of the eye and facial/ocular muscles using electrooculography (EOG) and the effects of visible light and sound sti...