EFFECTS OF METFORMIN AND GLIBENCLAIMIDE COMBINATION IN IRAQI OBESE PATIENTS WITH METABOLIC SYNDROME
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 10
Abstract
Objective: The prevalence of diabetes mellitus and obesity was increased world-wide as well as in Iraq. Inflammation plays important role in pathogenesis of obesity and type 2 DM. The aim of this study was to investigate the serum levels of the inflammatory markers, insulin resistance, and BMI and lipid profile in obese type 2 diabetic Iraqi patients treated with metformin and glibenclamide.Methods: This cross sectional study was conducted at Baquba Teaching Hospital, Diyala, Iraq; from January - April 2014. Fasting blood of glucose and insuline levels, lipid profile (S. cholesterol, S. triglyceride, and S. HDL), S. Interleukin 6 (IL-6) and C-reactive protein were determined in 30 subjects; 15 healthy control and 15 diabetic obese patients.Results: There was statistically significant difference in BMI, fasting blood sugar, insulin resistance and lipid profile between obese diabetic and control group; inflammatory markers were also significantly elevated in diabetic obese patients compared to healthy control.Conclusion: There is augmented inflammatory response in Iraqi diabetic obese patients which plays role in higher insuÂlin resistance in these patients. Levels of inflammatory markers are increased and related to BMI and dyslipidemia in these patients. Â
Authors and Affiliations
Haedar Abdulhafith Al-biati, Ahmed Salih Sahib, Sajida Hussein Ismail
Keywords
Related Articles
- EP ID EP579493
- DOI -
- Views 50
- Downloads 0
EFFECT OF VARMAM THERAPY IN SANTHU VATHAM (OSTEO ARTHRITIS–KNEE JOINT)-A SINGLE CASE STUDY
Santhu vatham is a vatha disease mentioned in the Siddha text book Yugi vaidhya chindhamani. The clinical features can be equated to osteo arthritis of knee joint. Varmam therapy is one of the external therapies mentione...
EFFECT OF A BINARY BLEND COMPOSED OF POLOXAMER AND PVP ON AQUEOUS SOLUBILITY OF GRISEOFULVIN
Objective: The aim of this study was to improve the aqueous solubility of a poorly water soluble drug griseofulvin.Methods: To accomplish this goal a technique of solid dispersion with polyvinyl pyrolidone (k30) and polo...
TREATMENT OF TINEA VERSICOLOR CAUSED BY MALASSEZIA FURFUR WITH DILL SEED EXTRACT: AN EXPERIMENTAL STUDY
Objective: Pityriasis versicolor (PV) is a superficial fungal infection of the skin characterized by changes in skin pigment due to colonization of the stratum corneum by a dimorphic lipophilic fungus of the normal flora...
SIMULTANEOUS DETERMINATION OF METFORMIN, LINAGLIPTIN IN JENTADUETO AND METFORMIN, SAXAGLIPTIN IN KOMBIGLYZE BY LC-MS METHOD
Objective: The objective of the present investigation was to develop a novel, simple and economic method for the determination of metformin (MET), linagliptin (LIN) and saxagliptin (SAX) in jentadueto and kombiglyze samp...
EFFECTS OF A. MELLIFICA EXTRACT ON THE HEMATOLOGICAL, BIOCHEMICAL, URINE AND HISTO-PATHOLOGICAL PARAMETERS OF WHITE ALBINO RABBITS
Objective: To observe the effects of Apis mellifica extract on different hematology, biochemistry and histopathology parameters in rabbits for determining its safety and efficacy.Method: Hematological, biochemical invest...