Effects of methadone and morphine on c-Fos expression in the rat brain: Similarities and differences.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 1
Abstract
This is the first study designed to compare the pattern of stimulation of c-Fos in selected brain structures after an acute administration of morphine and methadone. Methadone and morphine induced activation of c-Fos protein in the terminal forebrain projecting areas of the brain dopaminergic system, i.e. the striatum and nucleus accumbens. Taking into account generally accepted differences in the potency of pharmacological effects of the two drugs, it is surprising that this effect was most evident after the dose of 5 mg/kg of either drug.
Authors and Affiliations
Ewa Taracha, Małgorzata Lehner, Aleksandra Wisłowska-Stanek, Piotr Maciejak, Andrzej Bidziński, Anna Skórzewska, Danuta Turzyńska, Adam Płaźnik
Keywords
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