Effects of methanol extract of Salacia senegalensis leaves on some biochemical and haematological indices of albino mice.
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 3
Abstract
Background and Aims: Herbal medicine is one of the crucial regime disease treatment and management in African. Nevertheless, Salacia senegalensis among many of the plants used are yet to be authenticated scientifically. Therefore the effects of the leaves of methanol extract of Salacia senegalensis on some biochemical and haematological parameters were assayed. Method: The albino mice (six per group) weighing 18-22 g used for the haematology and biochemical studies were grouped into A (control) given 5 mL normal saline/kg/body weight per day, B (given 1000 mg), C (given 1200 mg) and D given 1400 mg extracts respectively/kg body weight per day for one week. Spectrophotometry and colourimetry methods (Haematology Autoanalyzer) were used in the assay. Biochemical parameters assayed were serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total protein, while haemoglobin (Hb), platelets (Plat), total white blood cell (WBC), lymphocyte (Lymp) and neutrophil (Neut) levels were the haematological indices measured. Results: The haematological results showed that the extract produced a dose-dependent increase in haemoglobin concentration in all the animal groups which were significantly higher than that of mice in the control group (P < 0.05). The platelets levels were significantly reduced compared to the control group, while the white blood cells, lymphocytes and neutrophils levels of the animals in groups B-D were significantly increased compared to the control (P < 0.05). The biochemical results showed that the serum aspartate aminotransferase and alanine aminotransferase levels were significantly increased compared to the control (P < 0.05), while a decrease was observed in protein levels compared to the control (P > 0.05). The weights of the animals were not significantly altered compared to the control group. Photomicrographs of the extract-treated albino mice livers showed a moderate inflammatory response at the extract doses used. Conclusion: The results suggest a mild hepatotoxic effects after one week (prolonged) treatment with the methanol extract of Salacia senegalensis leaves at various doses used.
Authors and Affiliations
*Adumanya, OCU. , Onwubuche, BC. Okorocha, UG.
Keywords
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- EP ID EP563412
- DOI 10.22192/ijcrms.2018.04.03.019
- Views 126
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