Effects of Methanolic Extract of Trichosanthes CucumerinaSeed on Experimentally-Induced Prostatic Hyperplasia
Journal Title: International Journal of Contemporary Research and Review - Year 2018, Vol 9, Issue 1
Abstract
Benign prostatic hyperplasia,a non-cancerous condition of unknown cause, is the most common prostate diseasein men globally. The present study investigated the possible ameliorative effectsofmethanolic extract of Trichosanthes cucumerinaseeds (METCS)on experimentally-induced prostatic hyperplasiain Wistar rats.Twenty adult,male Wistar rats weighing 150-250g were randomly divided into four groups of five animals each. Group I, normal control,was given corn oil only; Group II, hormone-treated control(HTC),Groups IIIand IV,hormone-and extract-treated, received continuous dosesof 300μg and 80μg of testosterone and estradiol,respectively,on alternate days for three weeks subcutaneously in the inguinal region;while the extract-treatedratsreceived additional 400mg/kg b.w.(low dose) and 800mg/kg b.w.(high dose) of METCSorally for another threeweeks.Immediately after inductionofbenign prostatic hypertrophy,some animals were randomly selected and sacrificed for gross inspection of prostate enlargement, prostate specific Adefule A. K et al. Effects of Methanolic Extract of Trichosanthes CucumerinaSeed on Experimentally-Induced Prostatic HyperplasiaInternational Journal ofContemporary Research and Review, Vol. 9, Issue. 01, Page no: MS20396-20404doi: http://dx.doi.org/10.15520/ijcrr/2018/9/01/401Page | 20397antigen analysis(PSA)and sperm count evaluation.These procedures were repeated again after three weeks of extract treatment. Theprostateswere harvestedand processed routinely for paraffin embedding,and stained with hematoxylin and eosin(H&E).Resultsobtained showed significant(P<0.05)reduction in PSA levels following high doses of METCSand also a reversal of histological hyperplasic changes
Authors and Affiliations
Adefule A. K.
Keywords
Related Articles
- EP ID EP546566
- DOI 10.15520/ijcrr/2018/9/01/401
- Views 61
- Downloads 0
Evaluation ofRouting Protocols inWirelessAd-HocNetworks under SecurityAttacks
Wirelessnetworkshavecertainly beenarevolutionintoday’stechnologyasoneofthe mostvitalandactivefieldsinthe communicationindustries.These wireless ad-hoc networksconsists ofindependentnodes withdecentralizedadministration...
The Need for Deliberate Spiritual Formation for Children Living With Global Developmental Delays
Within the life of a congregational community, faith is formed, shared, and strengthened; relationships are forged and deepened; and gifts are discovered, developed, and dispensed. Unfortunately too many ch...
Lake Fishing Factors on Pupils School Attendance Pattern in Developing Countries. A Case of Madiany Division, Siaya County Kenya
Developing countries education system includes both academic and technical training at primary, secondary and tertiary levels (Ward et al. 2006). Formal primary schooling lasts for eight yearsand seven year...
Reading Meaningful Children's StoriesUsing Critical Questions
Reading ability andreading interest of Indonesian society is very low. This is partly due to the meaningless reading reading that children have an impact on the lazy reading experienced by children. In ord...
Study of Forest Resources in Mukundpur Forest Range of Satna, Forest Division, Madhya Pradesh
Mukundpur forest range is situated in Amarpatan Tahsil of Satna district of Madhya Pradesh India. The range has geographical area of 589.71 km2with forest area 111.55 km2. Thisstudy area is u...