Effects of Methanolic Extract of Trichosanthes CucumerinaSeed on Experimentally-Induced Prostatic Hyperplasia
Journal Title: International Journal of Contemporary Research and Review - Year 2018, Vol 9, Issue 1
Abstract
Benign prostatic hyperplasia,a non-cancerous condition of unknown cause, is the most common prostate diseasein men globally. The present study investigated the possible ameliorative effectsofmethanolic extract of Trichosanthes cucumerinaseeds (METCS)on experimentally-induced prostatic hyperplasiain Wistar rats.Twenty adult,male Wistar rats weighing 150-250g were randomly divided into four groups of five animals each. Group I, normal control,was given corn oil only; Group II, hormone-treated control(HTC),Groups IIIand IV,hormone-and extract-treated, received continuous dosesof 300μg and 80μg of testosterone and estradiol,respectively,on alternate days for three weeks subcutaneously in the inguinal region;while the extract-treatedratsreceived additional 400mg/kg b.w.(low dose) and 800mg/kg b.w.(high dose) of METCSorally for another threeweeks.Immediately after inductionofbenign prostatic hypertrophy,some animals were randomly selected and sacrificed for gross inspection of prostate enlargement, prostate specific Adefule A. K et al. Effects of Methanolic Extract of Trichosanthes CucumerinaSeed on Experimentally-Induced Prostatic HyperplasiaInternational Journal ofContemporary Research and Review, Vol. 9, Issue. 01, Page no: MS20396-20404doi: http://dx.doi.org/10.15520/ijcrr/2018/9/01/401Page | 20397antigen analysis(PSA)and sperm count evaluation.These procedures were repeated again after three weeks of extract treatment. Theprostateswere harvestedand processed routinely for paraffin embedding,and stained with hematoxylin and eosin(H&E).Resultsobtained showed significant(P<0.05)reduction in PSA levels following high doses of METCSand also a reversal of histological hyperplasic changes
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Adefule A. K.
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- EP ID EP546566
- DOI 10.15520/ijcrr/2018/9/01/401
- Views 122
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