Effects of Oral Administration of Aqueous Extract of Tridax Procumbenson Body Organs and Hematological Parameters
Journal Title: International Journal of Contemporary Research and Review - Year 2017, Vol 8, Issue 4
Abstract
The study profiled the effectsof oral administration ofthree non-therapeutic doses (400,632 and 1000mg/kg body weight) of aqueousextract ofTridax procumbens on body organs and hematologicalparameters on male Swiss albino mice. The experimental mice were housed at room temperature with 12hours/12hours darkness photoperiod, provided with rodent standard pellets and water ad libitum.Hematological profileand organs toxicity assay wereexecuted using standard laboratory procedures. The result demonstrated a significant (ρ≤0.05) decrease in the weekly weight gain by the experimental mice, relative to the control mice.The normalized weight of the organs remained significantly unaffected except the lungs which weresignificantly increased at 400mg/kg body weight, relative to the control. Moreover, there was no significant change in the levels of the hematological indices except the monocytes,wherea significant increase was observed at 632mg/kg body weight, relative to the control. Theplant extract demonstrated only very mild toxicity and hence recommended for use where beneficial pharmacological activityof the plant extracthas been established
Authors and Affiliations
Njangiru IK1*, Njeri LK2
Keywords
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- EP ID EP314208
- DOI 10.15520/ijcrr/2017/8/04/164
- Views 76
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