Effects of Pre Anaesthetic, Single Low Dose Dexmedetomidine on Induction and Haemodynamic Parameters in Laparoscopic Cholecystectomy
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 2
Abstract
Background and Aims: The present prospective random and double blind study was designed to test the effect of single low dose dexmedetomidine on induction, haemodynamic parameters in patients undergoing laparoscopic cholecystectomy. Material and Methods: For the proposed study total of 80 patients of age group 18-60 years, ASA grade I and II were taken after fulfilling inclusion criteria and verifying exclusion criteria. Patients were randomly allocated into 2 groups of 40 patients each. Group A (Control n=40): Patients recieved normal saline (0.9% NaCl) 20ml. Group B (Study n=40): Patients recieved dexmedetomidine 0.75g/kg I/V prepared in normal saline to make a total volume of 20 ml. Cardiovascular parameters were observed continuously but recorded during intubation, every 3 minutes interval after intubation upto 30th minute and then after every 10 minutes interval intra operative extending upto 90th minute post-operative. Monitored for any incidence of complications for next 90 minutes. Modified Aldretes scores were recorded at 10, 20, 30, 40, 50, 60, 90 min. Modified Aldrete scoring >9 was considered criteria for recovery. Results: Dexmedetomidine 0.75g/kg I/V has significant attenuating effect on heart rate, systolic blood pressure, and diastolic blood pressure and mean arterial pressure during laparoscopic cholecystectomy. Dexmedetomidine produces dose-dependent anxiolysis, and analgesia so decreases the dose of requirement of anaesthetic agent for induction. There is a significant reduction in the adverse effects both intraoperatively and postoperatively in dexmedetomidine group of patients. Conclusion: Single dose preanaesthetic dexmedetomidine significantly attenuates stress responses to various noxious stimuli during surgery, maintains haemodynamic stability, reduces the requirement of other anaesthetic agents without prolongation of recovery.
Authors and Affiliations
Balwinder Kaur Rekhi, Harnam Singh Rekhi, Sahil Satish Arora, Kamini Singla, Sandeep Sidhu, Sushil Mittal, Amita Mhatre Arora
Keywords
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- EP ID EP544718
- DOI 10.21276/ijmrp.2017.3.2.046
- Views 73
- Downloads 0
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