Effects of Pregnancy on CD4 and CD8 T-Lymphocyte subsets and Determination of Best Parameter for Assessing Immunity in Pregnancy
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 5
Abstract
Objective: The aim of this study was to assess the effect of pregnancy on CD4+ and CD8+ cell counts, CD4/CD8 ratio and CD4 and CD8 percentages and also determine which of these parameters will be most reliable in assessing immunity in pregnancy. Study design: This was a case-control study involving 80 healthy HIV seronegative pregnant women and 81 healthy HIV seronegative non-pregnant women. Their HIV status was determined after obtaining an informed consent. Their Full Blood Count, CD4+ cell count and CD8+ cell count were measured by standard laboratory methods. CD4%, CD8% and CD4/CD8 ratio were calculated from results obtained. All data collected were subjected to statistical analysis using Epi Info.
Authors and Affiliations
Babah OA
Keywords
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