Effects of Red Guajava Leaf Extract (Psidium Guajava. L) Active Substance on FSH Level and Spermatogenesis in Male White Rats (Rattus Norvegicus)
Journal Title: Jurnal Ners - Year 2016, Vol 11, Issue 2
Abstract
Introduction: The census in 2010 showed that the population of Indonesia was as many as 237.6 million with a population growth rate of 1.49% per year. RPJPMN target in 2010-2014 was 1.14%, so the current population growth rate, which is 0.53%, is still high. It is necessary to control population growth. One method to control population is the use of contraception by using contraceptive both in males and females. Male involvement in family planning remains low, only 6.26%. The purpose of this study was to proved that the active substance of red guava leaves can reduce spermatogenesis in male rats (Rattus norvegicus). Methods: This was an experimental study using post-test only control group design. Sample size from Federer's formula obtained 30 white rats. Samples were divided into three groups: Group 1 (K1), the control group, was given with 0.5% CMC Na solution of 1 ml/day. Treatment group 1 (P1) was given red guajava leaf extract in a dose of 40 mg/ml/day, and the treatment group 2 (P2) was given with red guajava leaf extract in a dose of 80 mg/ml/day for 30 days. The variables in this study were spermatogenic cell count. Data were analyzed using ANOVA test. Result: Results of ANOVA data analysis, number of spermatogonial cells had p value 0.801 (p <0.05), it means there was no significant difference among the three groups, LSD test was not conducted. ANOVA test results for a number of primary spermatocytes cells showed p value 0.102 (p< 0.05), there were no significant differences among the three groups, LSD test was not conducted. ANOVA test results for a number of spermatid cells p value of 0.001 (p <0.05) means that there were significant differences among the three groups. LSD test results with P1 control (p 0.036): different, with P2 controls (p <0.000): different, P1 to P2 (p <0.033): different. Discussion: The conclusion of this study was that the administration of guajava leaf extract does not reduce spermatogonium and spermatosit primer but reduce spermatid count in male rats.
Authors and Affiliations
Ervi Husni, Sukesi Sukesi
Keywords
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- EP ID EP191901
- DOI 10.20473/jn.V11I22016.269-276
- Views 77
- Downloads 0
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