Effects of regulatory T cells, natural killer cells, and natural killer T cells on immunosuppression therapy in patients with recurrent embryo implantation failure
Journal Title: Clinical and Experimental Obstetrics & Gynecology - Year 2019, Vol 46, Issue 4
Abstract
Objective: This retrospective study aims to investigate the effects of immunosuppressive therapy on the expression of regulatory T (Treg) cells, natural killer (NK) cells, and natural killer T (NKT) cells in patients with recurrent embryo implantation failure (RIF). Materials and Methods: In vitro fertilization and embryo transplantation (IVF-ET) at Jinhua Municipal Central Hospital from July 2013 to November 2015 of 30 RIF patients were enrolled into RIF group, and peripheral blood Treg, NK, and NKT were detected before entering the embryo transfer cycle. Meanwhile, 20 normal non-pregnant women were enrolled into control group. Twenty-four patients in RIF group were administered prednisone; Treg, NK, and NKT cell contents were detected twice before and after the embryo transfer cycle, respectively. The remaining six patients with high NK cell contents were treated with gamma globulin via intramuscular injection, and Treg, NK, and NKT cell contents were detected twice before the embryo transfer cycle and after treatment. Results: Treg cell content was significantly lower in RIF group than in control group, while NK cell proportion was significantly higher in RIF group than in control group before treatment. There was no statistical difference in NKT cells. After treatment, expression rate of Treg in RIF group was 7.1 ± 1.8%, which compared with that before treatment (2.8±1.6%) was significantly higher (p < 0.01). In addition, NK cell proportion was significantly lower than pretherapy (20.9 ± 3.6% vs. 38.6 ± 8.1%, p < 0.05) and NKT cell percentage did not present the obvious difference before and after treatment. Conclusion: The occurrence of RIF may be related to the decrease in Treg expression and increase of NK cells. Immunotherapy can upregulate the expression of Treg and decrease NK cell proportion, thereby regulating maternal fetal immune tolerance and reducing the rejection effect of NK cells on fetal foreign bodies, which are conducive to embryo implantation.
Authors and Affiliations
J. He, L. Zou, S. Zhuang
Keywords
Related Articles
- EP ID EP673402
- DOI 10.12891/ceog4816.2019
- Views 96
- Downloads 0
A live normal baby is possible despite exposure of a cleaving embryo in culture to extensive smoke and heat from a raging fire and exposure to chemicals used to extinguishing the fire
Purpose: To demonstrate that some embryos can be exposed to fire and smoke and still be rescued and result in a healthy baby following embryo transfer. Materials and Methods: Valiant efforts were made to save cleaving em...
Predictive value of neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio and mean platelet volume for pelvic inflammatory disease
Purpose: The aim of this study was to investigate the efficacies of neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR) and mean platelet volume (MPV) as early markers in patients with pelvic inflamm...
The effect of maternal body mass index on the placental thickness
Introduction: The increase in the placental thickness (mm) in the second trimester of pregnancy is associated with placenta-mediated pregnancy complications. The authors aimed to evaluate the effect of maternal BMI (kg/c...
Long-term treatment of endometriosis with dienogest for up to five years
Purpose of Investigation: Dienogest is marketed in Japan as the first time in the world for novel treatment of endometriosis. This paper details the retrospective investigation how effective long-term use of dienogest is...
Accuracy of transvaginal ultrasound, saline infusion sonohysterography, and office hysteroscopy in the diagnosis of endometrial polyps
Background: Endometrial polyps (EPs) derive from overgrowths of stromal or endometrial glands supported by a fibrovascular core. Currently, there is no clear recommendation on the first-line tool to be employed between s...