Effects of Resveratrol on pharmacokinetics and pharmacodynamics of Pioglitazone in Diabetic rats
Journal Title: Perspectives In Medical Research - Year 2017, Vol 5, Issue 1
Abstract
Introduction: Diabetes is a group of metabolic disorders characterized by achronic hyperglycaemic condition resulting from insufficient action of insulin. CYP inhibiting drugs increase the concentration of the drugs that are substrates for the specific CYP isoforms and thus enhance the pharmacological and toxicological effects of the substrate drugs. Pioglitazone is a CYP3A4 substrate and resveratrol is a strong inhibitor. Hence, there is a chance of influence on the pharmacokinetics and pharmacodynamics of Pioglitazone. Aims & Objectives :To capture the knowledge, attitude and self-medication practices among medical and non-medical professional course students in Tagore Educational Institutions, Chennai and to assess the effect of ‘whatsapp’ smartphone application intervention on self-medication practices among the experimental group. Materials &Methods :The study was performed on male wistar rats, divided into five groups. Diabetes was induced by administration of Streptozotocin 45mg/kg in 0.1M citrate buffer. Diabetic rats weretreated with resveratrol before administration of pioglitazone. Blood samples were collected from orbital puncture at various time intervals and analysed for blood glucose and pharmacokinetics of pioglitazone by HPLC. Results :Mean serum concentration (mcg/ml) of pioglitazone increased in diabetic rats supplemented with resveratrol. Conclusion :The results of increased pioglitazone levels as a result of its metabolic inhibition under resveratrol exposure suggests an interaction which may be due to decreased metabolism of pioglitazone as a result of CYP3A4 and CYP2C8 inhibition.
Authors and Affiliations
Raju Devde
Keywords
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