Effects of Simvastatin and Ezetimibe on Rats’ Parotid in Experimental Freund’s Adjuvant Arthritis
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 6
Abstract
Statins and ezetimibe, except from their lipid lowering action, have been reported to exert anti-inflammatory effects. It is interesting to investigate if there is any clinical efficacy of these drugs on rheumatoid arthritis. The aim of the present study was to investigate the effect of simvastatin and ezetimibe on parotid glands’ morphological alterations and on serum indexes in arthritic rats. Twenty-eight Wistar rats were divided into 4 groups. Group A, B and C were injected with 0.1ml Freund’s complete adjuvant in the paw. After the arthritic symptoms’ manifestation, Group B received simvastatin 0.1mg/100g per os and group C ezetimibe 3mg/kg for 14 days. Group D served as control. Total proteins, rheumatoid factor, TNF-a, paw diameter, parotid and adrenal weight, as well as parotid histology were negatively affected under the influence of Freund’s complete adjuvant. Simvastatin and ezetimibe administration significantly ameliorated all the above parameters. An amelioration in adjuvant arthritic laboratory findings and in parotid histology was demonstrated under simvastatin and ezetimibe administration, implying that both drugs possess a potential antiinflammatory action.
Authors and Affiliations
Nikos Seferos
Keywords
Related Articles
- EP ID EP370265
- DOI -
- Views 74
- Downloads 0
Varied Clinical Presentations of Meckel’s Diverticulum
Meckel's diverticulum is a common congenital anomaly of the gastrointestinal tract. They are largely asymptomatic; complications are rare and include diverticulitis, bleeding and obstruction. This is a report on three ca...
A Comparative Study of Spleen Size Determination by Ultrasonography in Males of Bilious and Phlegmatic Temperament as a Part of Hai’at-Ul A’za (Body Physique)
The present study was carried out with an aim to determine the spleen size on the parameters of Hai’at-ul-A’za with the help of ultrasonography among the Safravi (Bilious) and Balghami (Phlegmatic) healthy male participa...
Prevalence of High-Risk Human Papilloma Virus (HR-HPV) As a Risk Factor in HNSCC Patients of Saurashtra Region of Gujarat
Background: In India HNSCC comprises the largest group of malignancies with an incidence rate as high as 30-40%.The present study was carried out to determine the prevalence of high-risk human papilloma virus (HR-HPV) as...
Effect of a Voice Training Program on Acoustic Voice Parameters in Secondary School Teachers
Teachers are known to be vulnerable to voice disorders because of the excessive use of their voice for professional purposes. This study aimed to investigate the effects of a vocal training program on select acoustic voi...
Nail Patella Syndrome with Secondary Osteoarthritis of Hip - A Rare Case Report
Nail-patella syndrome (NPS) or Hereditary onycho-osteodystrophy is a rare autosomal dominant condition characterised by skeletal and nail abnormalities and frequently renal involvement. Our patient presented with both hi...