Effects of Simvastatin and Ezetimibe on Rats’ Parotid in Experimental Freund’s Adjuvant Arthritis
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 6
Abstract
Statins and ezetimibe, except from their lipid lowering action, have been reported to exert anti-inflammatory effects. It is interesting to investigate if there is any clinical efficacy of these drugs on rheumatoid arthritis. The aim of the present study was to investigate the effect of simvastatin and ezetimibe on parotid glands’ morphological alterations and on serum indexes in arthritic rats. Twenty-eight Wistar rats were divided into 4 groups. Group A, B and C were injected with 0.1ml Freund’s complete adjuvant in the paw. After the arthritic symptoms’ manifestation, Group B received simvastatin 0.1mg/100g per os and group C ezetimibe 3mg/kg for 14 days. Group D served as control. Total proteins, rheumatoid factor, TNF-a, paw diameter, parotid and adrenal weight, as well as parotid histology were negatively affected under the influence of Freund’s complete adjuvant. Simvastatin and ezetimibe administration significantly ameliorated all the above parameters. An amelioration in adjuvant arthritic laboratory findings and in parotid histology was demonstrated under simvastatin and ezetimibe administration, implying that both drugs possess a potential antiinflammatory action.
Authors and Affiliations
Nikos Seferos
Comparative Study of Kundur (Boswellia Serrata) and Tareeq (Diaphoresis) In the Management of Samne Mufrit (Obesity) - A Randomised Clinical Trial
Background & Objectives: Obesity is emerging as a major health problem worldwide which still defies all sorts of treatment approaches and stares in face attending morbidity and mortality. The aim of the study was to eval...
Effect of a Voice Training Program on Acoustic Voice Parameters in Secondary School Teachers
Teachers are known to be vulnerable to voice disorders because of the excessive use of their voice for professional purposes. This study aimed to investigate the effects of a vocal training program on select acoustic voi...
Improving Sleep Quality through Heartfulness Meditation- Technical Aspects and Benefits
Sleep is a vital function of the body that is essential for our physical and mental well-being. In today’s world, sleep deprivation is becoming a major epidemic affecting both men and women across all age groups. Globali...
Study of Clinico-Cytological Profile of Female Patients from Rural Areas of Telangana Presenting to a Tertiary Care Centre with Gynecological Complaints
Introduction: Cancer cervix being the most common cancer of the female population in India needs early screening and interventions in high-risk females. Pap smears is the gold standard method of screening women of all ag...
Out of Pocket Expenditure for Yellow Fever Vaccination in India
Introduction: Yellow fever is an acute viral hemorrhagic disease transmitted by infected Aedes mosquitoes. Though the cost of yellow fever vaccine is Rs 300/- only, as fixed by the government of India, the actual expendi...