Effects of Some Food Additives on Some Biochemical Parameters in Young Male Albino Rats and the Ameliorative Role of Royal Jelly
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2017, Vol 67, Issue 0
Abstract
Background: the use of food additives is one of the most important problems in the human health nutrition field. Food additives are widely used for various purposes; including preservation, coloring, and sweetening, however, the physiological and biochemical changes may be produced. Aim of the work: was to investigate the protective role of royal jelly (RJ) against abnormalities in metabolic biochemical parameters that induced by these food additives in male albino rats. Materials and Methods: thirty young male albino rats with an average body weight 120-140 g were divided into three groups (10/cage); Group I: served as normal control group, Group II: rats orally administrated with the mixture which consists of sodium nitrite (NaNO2 0.1 mg/kg b.wt./ day), annatto (0.065 mg/kg b.wt./day) and monosodium glutamate (MSG 15 mg/kg b.wt./day) and Group III: rats orally administrated with the previous mixture and then orally administrated with royal jelly (14.28 mg/kg b.wt./day soluble in maize oil). At the end of the experiment, blood samples were collected for biochemical estimations which including levels of serum glucose, creatinine, urea, testosterone, thyroid hormones (T3 and T4), activities of AST and ALT, total protein (TP), albumin, total cholesterol, triglycerides, high-density lipoprotein (HDL-c) and low-density lipoprotein (LDL-c). Results: the present study showed marked elevation in levels of fasting blood glucose, activities of AST, ALT, levels of serum urea, creatinine, TC, TG, LDL-c, VLDLand ratios of TC/HDL-c and LDL-c/HDL-c (risk factors) as well as albumin /globulin ratio and serum thyroid hormones (T3&T4) accompanied with significant reduction in the body weight, serum total proteins, albumin, globulin, albumin/creatinine, testosterone and HDL-C concentrations in the group that administrated with the mixture which consists of (NaNO2, MSG and annatto) as compared to control rats. While administration with royal jelly significantly ameliorated the disturbed biochemical parameters and showed significant improvement in most of these parameters. Conclusion: it could be concluded that royal jelly offers a therapeutic advantage that minimizes the metabolic abnormalities and biochemical changes which induced by these food additives.
Authors and Affiliations
Eman G. E. Helal email orcid 1; Rasha A. A. El-Sayed1; , GomaaMostafa Hedeab2; Mariam S. El-Gamal1
Keywords
Related Articles
- EP ID EP499466
- DOI -
- Views 132
- Downloads 0
Comparative Study between Anterior Chamber Iris Claw Phakic Iol and Posterior Chamber Phakic Iol (Icl) for Correction of Myopia3508
<span>Background: </span><span>Compared to other refractive surgeries, implantation of phakic intraocular lenses (pIOLs) have more desirable results and are potentially reversible procedures due to the possibility of exp...
Role of Electrocardiogram-Gated Multidetector Computed Tomography in Diagnosis of Congenital Heart Disease
Aim of the work: this study aimed to assess the role of ECG gated multidetector computed tomography in detection and characterization of congenital heart diseases. Patients and method: this study was carried out in the R...
A prospective study of the latero-central glandular pedicle technique as an oncoplastic procedure for medial quadrants breast masses:oncological safety and clinical outcomes
<strong>Background: </strong>breast cancer, according to national cancer institute, is the most common site of cancer in women in Egypt as it accounts for about 38.8% of total malignancies among Egyptian females; it is a...
Role of ADC Map MR Imaging in Prediction of Local Aggressiveness of Prostate Cancer
<strong>Objective:</strong> of this study is to evaluate the relationship between ADC map values of MR imaging and local aggressiveness of the prostate Cancer via comparing the ADC values and Gleason score in prostate Ca...
Corneal Endotheleal Cells Changes After Phacoemulsification in Type II Diabetes Mellitus
Background: Corneal endothelial cells are responsible for the clarity of the cornea; however, endothelial cells have limited cell division ability. Studies have proven that cornea is more vulnerable to chronic changes af...