Effects of systemic toxicity produced by fluoride: in vivo study
Journal Title: Stomatos - Year 2018, Vol 24, Issue 47
Abstract
This study sought to verify possible systemic changes caused by fluoride administered at different concentrations. An animal model was used in which 60 rattus norvegicus were randomly divided into 4 groups, with three test groups receiving fluoridated water at the different concentrations (0.7 ppm F, 1.2 ppm F and 2, 0 ppm F), and a control group receiving distilled water. A histomorphological analysis was performed by light microscopy after the dissection of the following rat organs: the large intestine (duodenum), the kidney and the liver. The results obtained after the comparative descriptive evaluation of the study groups showed morphological changes in all the test groups, concluding that the fluoride administered at these concentrations could be toxic.
Authors and Affiliations
Alessandra Dutra da Silva, Andreza Lapis Schinelli, Carolina Coradini Abascal, Marcia Kijner, Sabrina Pozatti Moure, Paulo Oliva de Borba
Keywords
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