Effects of Vildagliptin on Glucose Control in Patients with Type 2 Diabetes Inadequately Controlled With Metformin
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 6
Abstract
Aim and Objective: We sought to evaluate the efficacy and safety of vildagliptin, a new dipeptidyl peptidase-4 inhibitor, added to metformin during 24 weeks of treatment in patients with type 2 diabetes. Patient selection and method: The study was done in 100 patients of Type 2 DM who were inadequately controlled by metformin alone. Strict predefined inclusion and exclusion criteria were followed and each patient was monitored with physical examination including body weight and blood pressure, complete blood count, fasting blood glucose and post prandial blood glucose, HbA1c, lipid profile (TC, LDL – C, HDL – C, triglycerides), renal profile (B Urea, S Creatinine, routine urine examination, ACR – urine, test for microalbuminemia), liver profile (ALT, AST, ALP, S.Bilirubin, S Protein) and ECG. Efficacy and tolerability were assessed in eight visits over 24 weeks. Results: The decrease of mean HbA1c level was 1.13% in cases (Group A) as compared to 0.05% in the control (Group B) at 24 week which was found to be significant (P value <0.01). Reduction in the mean fasting blood glucose level in cases (Group A) was 28.83mg/dL as compared to 3.6mg/dL in control (Group B) at 24 weeks. This decrease was found to be significant (P value <0.01). Reduction in the mean post prandial blood glucose level in cases (Group A) was 41.44mg/dL as compared to 2.12mg/dL in control (Group B) at 24 week. This decrease was found to be significant (P value <0.01). No major changes from baseline to endpoint were observed for any hematological, biochemical or urinalysis parameter. Conclusion: Vildagliptin is well tolerated and produces clinically meaningful, dose-related decreases in A1C and FPG as add-on therapy in patients with type 2 diabetes inadequately controlled by metformin.
Authors and Affiliations
Dr Abhishek Anand
Keywords
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