Efficacy and Safety of a combination of Paracetamol, Chlorpheniramine maleate and Phenylephrine in the symptomatic treatment of Common Cold : Phase IV Clinical study
Journal Title: The Indian Practitioner - Year 2017, Vol 70, Issue 2
Abstract
Introduction and Background: Commoncold is one of the most frequently encountered disease in clinical practice. Though self-limiting, it accounts for major loss of work and school days so symptomatic therapy to treat the symptoms is often employed. A combination of Paracetamol, an antipyeretic/anti-inflammatory, Phenylephrine, a nasal decongestant and Chlorpheniramine maleate, an anti-histaminic is popular in the treatment of common cold. This Phase IV study evaluated the efficacy and safety of a combination of Paracetamol, Phenylephrine and Chlorpheniramine maleate in treatment of common cold. Methodology –Of 216 enrolled, 187 patients completed the study. Efficacy assessment was made by reduction in TSS and four point Likert-type scales. Safety assessment was made by analyzing the adverse events during trial. Results –Reductionin TSS from 6.58 (baseline) to 3.76 (day 3) and 1.78 (day 5). One point reduction in Likert-type symptom scale from Moderate to Mild took just 3 days. Nearly all the patients had >50% reduction in symptom score at all visit and majority of patients had complete relief from the symptom. 31 episodes of adverse events occurred and were of mild intensity. Conclusion – A combination of Paracetamol, Phenylephrine and Chlorpheniramine maleate is safe and effective in the treatment of common cold.
Authors and Affiliations
Kiran M, L Pawaskar, P Yadav
Keywords
Related Articles
- EP ID EP552424
- DOI -
- Views 103
- Downloads 0
Immune Thrombocytopenia (ITP): Adult Perspective
Immune thrombocytopenia (ITP) is an important clinical entity with a mortality rate of about 5% and is notoriously chronic in adult population. Since it is a diagnosis of exclusion, it becomes very important for the clin...
A rare presentation of viable intrauterine pregnancy with coexisting complete molar pregnancy in a uterus didelphys
Complete hydatidiform mole with co-existing live intrauterine fetus is an extremely rare event. Mullerian anomalies such as uterus didelphys are uncommon variants of normal anatomy. Uterus didelphys is one of the congeni...
Efficacy and Safety of a combination of Paracetamol, Chlorpheniramine maleate and Phenylephrine in the symptomatic treatment of Common Cold : Phase IV Clinical study
Introduction and Background: Commoncold is one of the most frequently encountered disease in clinical practice. Though self-limiting, it accounts for major loss of work and school days so symptomatic therapy to treat th...
Entrapment of penis to suppress sexual stimulation by ball bearing device
Entrapment of penis is a rare condition, done to enhance penile erection. It presents a situation that challenges the surgeon to be innovative in selecting the treatment. This condition can cause vascular compromise, eve...
Fever With Rash – a diagnostic Conundrum!
The differential diagnosis of fever and rash in an adult is varied and includes a variety of infectious and non-infectious causes. When confronted with a patient having fever with rash, making a timely and specific diagn...