Efficacy and Safety of a combination of Paracetamol, Levocetirizine and Phenylephrine in the symptomatic treatment of Common Cold and Allergic Rhinitis: Phase IV Clinical study
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2017, Vol 3, Issue 1
Abstract
Introduction: Common cold and allergic rhinitis are one of the most frequently encountered diseases in clinical practice. Though self-limiting, it accounts for major loss of work and school days so symptomatic therapy to treat the symptoms is often employed. A combination of Paracetamol, an antipyeretic/anti-inflammatory, Phenylephrine, a nasal decongestant and Levocetrizine, an anti-histaminic is popular in the treatment of common cold and allergic rhinitis. This Phase IV study evaluated the efficacy and safety of a combination of Paracetamol, Phenylephrine and Levocetirizine in treatment of common cold and allergic rhinitis. Methodology –Of 234 enrolled, 201 patients completed the study. Efficacy assessment was made by reduction in TSS and four point Likert-type scales. Safety assessment was made by analyzing the adverse events during trial. Results –Reductionin TSS from 6.82 (baseline) to 3.63 (day 3) and 1.14 (day 5). One point reduction in Likert-type symptom scale from Moderate to Mild took just 3 days. Nearly all the patients had >50% reduction in symptom score at all visit and majority of patients had complete relief from the symptom. 24 episodes of adverse events occurred and were of mild intensity. Conclusion – A combination of Paracetamol, Phenylephrine and Levocetirizine is safe and effective in the treatment of common cold and allergic rhinitis.
Authors and Affiliations
Dr. Mayuresh Kiran , Mr. Lalit Pawaskar Dr. Pramila Yadav
Keywords
Related Articles
- EP ID EP564371
- DOI 10.22192/ijcrms.2017.03.01.007
- Views 150
- Downloads 0
Anemia caused by iron deficiency in infants (A Review)
Iron deficiency and iron-induced anemia are among the most important health problems in the world, especially in Iran, which can impair development, lead to poor coordination of the nervous system, decrease learning powe...
Role of Gene Xpert Mtb/Rif in Diagnosis of Tuberculous Pus
Background- Extra-pulmonary tuberculosis (EPTB) remains a crucial challenge for the physicians with respect to timely diagnosis and treatment. The most common appearance of EPTB is tuberculous lymphadenitis with cervical...
Antioxidant activity of Mathiyooshna Rasayanam
Mathiyooshna Rasayanam is an excellent polyherbal formulation used in Siddha. It composed of 30 different herbal ingredients. It is mainly used for the treatment of degenerative disorder and wound healing. The aim of thi...
Isolation and Antimicrobial sensitivity pattern of Klebsiella pneumoniae from sputum samples in a tertiary care hospital
Background: Gram negative pathogens are an important cause of community and hospital acquired infections throughout the world. Klebsiella pneumoniae has become one of the more common cause of these infections and one of...
Seroprevalence of HIV antibodies in the patients of sexually transmitted infection
Background and Aims: AIDS, the acquired immunodeficiency syndrome is a fatal illness caused by a virus known as a human immunodeficiency virus (HIV) which breaks down body’s immune system, leaving the victim vulnerable t...