EFFICACY AND SAFETY OF AZILSARTAN COMPARED WITH TELMISARTAN IN HYPERTENSIVE PATIENTS.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2019, Vol 7, Issue 7
Abstract
Objective: Angiotensive receptor blockers (ARBs) are very potent antihypertensive agents , Telmisartan being the prototype and most widely used.This study was undertaken to compare the efficacy and safety of Azilsartan a new ARB with Telmisartan. Material and methods : This prospective study was carried out in patients attending the Department of Medicine, SCB Medical college, Cuttack. Patients with newly diagnosed with stage I-II essential hypertension of either sex within the age group of 18?65 years with blood pressure of ≥140/90 mmHg were included in the study. Severe hypertension >180/110 mm of Hg, hypersensitivity to ARBs, secondary hypertension with any other etiology, pregnant women, history of Drug/ Alcohol abuse, cardiac arrhythmias were excluded. Patients who gave consent for the study were divided into 2 random groups 1 and 2 ? the first received azilsartan and the second received telmisartan. Point of control was defined as blood pressure<140/90 mm of Hg after initiation of therapy. Results : 180 patients were randomized into two groups. Out of 90 patients included in group 1 who received azilsartan, 4 lost for follow up. Out of 90 patients included in group 2 who received telmisartan, 5 lost for follow up. There was no significant difference between the two drugs in both mean systolic and diastolic blood pressure at 24hrs, 1 month and 3 months and 6 months. Mean diastolic blood pressure at 24 hrs was reduced more with telmisartan compared to azilsartan which is significant. Hypotension related adverse effects occurred in 3% of the patients in azilsartan group while it occurred in 8% of them in telmisartan group. Conclusion: Azilsartan is an effective blood pressure lowering drug with its safety and efficacy comparable to that of telmisartan.
Authors and Affiliations
Lenka D. N. , Routray S. N.
Keywords
Related Articles
- EP ID EP616026
- DOI 10.21474/IJAR01/9337
- Views 83
- Downloads 0
ASSESSMENT OF LANGUAGE DELAY AMONG 0-3 YEAR CHILDREN ATTENDING THE WELL BABY CLINIC IN A TERTIARY CARE CENTRE USING LEST (0-3 YEARS).
The study is a cross sectional study of 200 children conducted using Language Evaluation Scale Trivandrum (LEST 0-3) in the age group birth to 3 years to assess the prevalence of language delay in children attending Well...
REAL-TIME REMOTE MONITORING URBAN AND ARCHITECTURAL 3D DIGITAL DESIGN AND SPATIAL SIMULTANEOUS SIMULATION.
Object: The present researchtakes advantage of wide spreadtechnologies such as GPS, VHF telecommunications, field sensors and techniques commonly used in telegeoprocessing and teleomonitoring procedures in order to remot...
DEVELOPMENT OF GERMINATED WHEAT FLOUR (TRITICUM AESTIVUM L.) PRODUCTS FORTIFIED WITH PUMPKIN SEED AND BEET GREEN POWDER AND THEIR ORGANOLEPTIC EVALUATION.
Germination enhances the quality of nutrients and bioactive compounds of cereals thereby increasing the content in proteins, amino acids, sugars, and vitamins as well as the anti-nutritional factors are reduced with the...
STATUS OF COMMERCIAL SHRIMP, FENEROPENEAUS INDICUS (INDIAN PRAWN) FROM PUTHIYAPPA HARBOUR, KOZHIKODE, KERALA WITH RESPECT TO CONSUMER SAFTEY.
The Levels of contaminants in fish are of particular interest, because of high potential risks to humans who consumes them. In the present study,commercially important marine Indian prawn- Fenneropeneausindicus samples w...
A COMPLETE AYURVEDIC REVIEW ON SUNISHANNAKA [MARSILEA QUADRIFOLIA LINN].
Sunishannaka (Marsilea quadrifolia Linn) is a known pteridophytic herb belonging to the family Marsileaceae. Extensive usage of Sunishannaka as an important green leafy vegetable is understood from Samhithas. It is inclu...