Efficacy and Safety of Garenoxacin versus Moxifloxacin in Acute Exacerbation of COPD: A Comparative Study
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 8
Abstract
Aim: The aim of the present study was to compare the efficacy and safety of Garenoxacin with that of Moxifloxacin for the treatment of patients of Acute exacerbations of COPD. Material and Method: This study was a prospective, open label, observational, comparative study; where clinically diagnosed COPD patients of either sex in age group of 25-70 years with clinical symptoms suggestive of Acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) were enrolled. After obtaining written informed consent, Patients were divided into two treatment groups. Group A Moxifloxacin 400 mg once daily for 5 days while group B received Garenoxacin 400 mg once daily for 5 days. Primary outcome measure (cure, improved, failure), that is clinical success rate is assessed at day 14. Result: Mean age (± 2SD) of the COPD patients in Garenoxacin group was 60.98 ± 10.67 whereas in Moxifloxacin group the mean age (± 2SD) was 57.80 ± 10.27. In Garenoxacin group, 14 patients achieved cure and rest 36 patients achieved improved whereas in Moxifloxacin group, 8 patients achieved cure, 41 patient achieved improvement and 1 patient did not respond to treatment and was termed failure. Observed adverse event were few, mild and self limiting in both group. Conclusion: 5-day course of Garenoxacin is therapeutically comparable to Moxifloxacin in terms of clinical effectiveness in AECOPD.
Authors and Affiliations
Dr D C Punera
Keywords
Related Articles
- EP ID EP214224
- DOI -
- Views 68
- Downloads 0
Para Spinal Mass with Multiple Differential Diagnosis- A Case report
A paraspinal mass may be caused by large number of conditions including an abscess, non specific lesions and benign & malignant conditions involving mesenchymal/soft tissues. The diagnosis of many such lesions may be don...
Correlation of spleen size with oesophageal varices in cirrhosis of liver
Esophageal varies is the most dreaded complications of cirrhosis of liver responsible for high mortality and morbidity in these patients. As per current guidelines these patients need to go periodic screening with upper...
A Comparative Study of Pro Seal Laryngeal Mask Airway, i-gel and Combitube under General Anaesthesia for Elective Surgical Patients Requiring Controlled Ventilation
Aim: The Pro Seal laryngeal mask airway (PLMA), i-gel and Combi Tube (CT) in past evaluated alone or in group comparisons but differing study designs make it difficult to compare the results. The aim of this study was to...
The Role of Diffusion-weighted Imaging in Patients with Brain Tumors
Diffusion-weighted imaging is an MR imaging technique in which contrast within the image is based on microscopic motion of water. It was first described in 1965 by two physical chemists, Stejskal and Tanner. Diffusion-we...
Efficacy of a Training Module for Self Study of Regional Anatomy of Head and Neck for Undergraduate Students
The introduction of multimedia technology into teaching has brought important changes in teaching. This study seeks to evaluate whether the use of a structured teaching module on gross and applied anatomy of the head nec...