Efficacy and Safety of Garenoxacin versus Moxifloxacin in Acute Exacerbation of COPD: A Comparative Study
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 8
Abstract
Aim: The aim of the present study was to compare the efficacy and safety of Garenoxacin with that of Moxifloxacin for the treatment of patients of Acute exacerbations of COPD. Material and Method: This study was a prospective, open label, observational, comparative study; where clinically diagnosed COPD patients of either sex in age group of 25-70 years with clinical symptoms suggestive of Acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) were enrolled. After obtaining written informed consent, Patients were divided into two treatment groups. Group A Moxifloxacin 400 mg once daily for 5 days while group B received Garenoxacin 400 mg once daily for 5 days. Primary outcome measure (cure, improved, failure), that is clinical success rate is assessed at day 14. Result: Mean age (± 2SD) of the COPD patients in Garenoxacin group was 60.98 ± 10.67 whereas in Moxifloxacin group the mean age (± 2SD) was 57.80 ± 10.27. In Garenoxacin group, 14 patients achieved cure and rest 36 patients achieved improved whereas in Moxifloxacin group, 8 patients achieved cure, 41 patient achieved improvement and 1 patient did not respond to treatment and was termed failure. Observed adverse event were few, mild and self limiting in both group. Conclusion: 5-day course of Garenoxacin is therapeutically comparable to Moxifloxacin in terms of clinical effectiveness in AECOPD.
Authors and Affiliations
Dr D C Punera
Keywords
Related Articles
- EP ID EP214224
- DOI -
- Views 102
- Downloads 0
Characteristics of surgically treated benign breast disease
Benign breast disease in women is a very common finding. A firm understanding of benign breast disease is important since sequential steps are necessary to distinguish lesions which impart a high risk of subsequent breas...
A Prospective Observational Study Comparing total Intravenous Anaesthesia (TIVA) and Inhalational Anaesthesia for Controlled Hypotension in Radical Reconstructive Surgeries of Oral Cancers
Context: Controlled hypotension in oromaxillofacial surgeries provides better visualization of surgical field and decreased blood loss. The aim of the study was to know whether TIVA using propofol was superior to inhalat...
Acute Hemorrhagic Adem - An Unusual Presentation of Dengue Treated with Plasmapheresis
Neurological manifestations after dengue are not very common& acute disseminated encephalomyelitis (ADEM) following dengue infections is still more infrequent. We report a male, 10 year old who developed Hemorhhagic ADEM...
‘Clinical Trial’ or ‘Critical Trial’ – A Scientific Affront on Human Rights
Change is the law of life, Law always supports changes for development and prosperity. Science is the inevitable tool for achieving progress in human civilization. The relationship of science and law is as old as the cre...
Impact of Disease Duration on Lipid Profile in Type 2 Diabetes Mellitus Patients
Aim: The aim of the study was to study the impact of disease duration on lipid profile in type 2 diabetes mellitus patients. Methods: Total 30 diagnosed type 2 diabetic subjects were taken .The anthropometric parameters...