EFFICACY AND SAFETY OF SUPPLEMENTS IN CANCER PATIENTS: A 10-YEAR REVIEW AND UPDATES
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2017, Vol 3, Issue 5
Abstract
Cancer treatment has been always challenging not only because of immediate results but also due to long term outcomes such as survival rates, disease-free intervals and quality of life. Classical treatments (surgery, chemotherapy and radiotherapy) were focused on the tumor itself, leading aside general patient health conditions. Later nutrition began to play a role on cancer treatments, because of its potential implications on long term evolution, especially when abdominal surgery was performed; nevertheless these first findings were related to macronutrients such as proteins. Considering the big number of cancer types and so many potentially beneficial macro and micronutrients, there were still a long way to go and even when many physicians and nutritionists were using a dietary approach as cancer adjuvant therapy, most of knowledge was empirical and no evidence based. On XXI Century experimental research was conducted to identify what’s real and what’s fake about cancer and nutrition. On this systematic review it’s summarized the state of the art and what we know so far regarding nutrition role on cancer patients outcome, i.e. nowadays we are aware that a polyunsaturated fatty acids rich diet may reduce inflammatory status on cervical cancer patients, trace elements such as selenium showed no impact on cancer outcomes when compared to placebo, but its is still recommended due to its effect diminishing chemotherapy side effects. Lycopene and soy isoflavones rich diet may be beneficial on relapsed prostate cancer leading to a slower diseases progression while folic acid is associated to a reduction of colorectal adenoma. On the other hand some nutrients could have deleterious effects such as 25-hydroxyvitamin D which seems to be associated with a slightly risk increase of breast as well on prostatic cancer, however further, larger researches are mandatory to continue the evolution of this novel therapeutic field.
Authors and Affiliations
Silvia Ussai
Keywords
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