Efficacy and safety of TNF inhibitors - results of randomized controlled clinical trials
Journal Title: Reumatologia - Year 2006, Vol 44, Issue 6
Abstract
TNF inhibitors were first approved for treatment of active rheumatoid arthritis (RA) in 1998. Since that time, a series of multicentre, randomized controlled trials have been evaluated in early and established RA, in patients who had not been treated with methotrexate (Mtx) as well as in those who had an inadequate response to traditional disease modifying antirheumatic drugs (DMARD), including Mtx. In these trials approximately 6000 RA patients have participated. Clinical response to treatment and adverse effects of anti-TNF agents are discussed. The relative expense of TNF inhibitors makes their universal use impractical. The use of TNF inhibitors in the treatment of active RA should be considered when traditional DMARD, including combination therapy of DMARD, are not effective.
Authors and Affiliations
Anna Filipowicz-Sosnowska
Bóle dolnego odcinka kręgosłupa u kobiet po 55. roku życia – analiza patogenetyczna
Celem pracy była ocena przyczyn bólów dolnego odcinka kręgosłupa u kobiet po 55. roku życia. Grupę badaną stanowiły 103 kobiety w wieku 67,6±7,1 lat, które kolejno zgłosiły się do lekarza z powodu bólu w odcinku lędźwi...
First EULAR/EUSTAR Scleroderma Course The assessment of the patient with systemic sclerosis Budapeszt, 13–16 stycznia 2005 r.
Neuroendocrone tumor of RA patient - a case report
Neuroendocrine tumor is a rare disease. In this article the case of the patient with non-typical symptoms and results of the visualisating methods was described.
Cyklosporyna A w leczeniu choroby Stilla
Choroba Stilla jest jedną z postaci młodzieńczego idiopatycznego zapalenia stawów. U chorych, u których objawy występują po 16. roku życia, określa się ją jako chorobę Stilla z początkiem w wieku dorosłym (adult onset S...
The operative treatment of the rheumatoid wrist
The surgical methods of treatment of the rheumatoid wrist are presented in this paper. Wrist synovectomy, wrist denervation, partial or total arthrodesis, interposition arthroplasty, prosthetic replacement and wrist stab...