Efficacy and Safety of Transdermal Diclofenac Patch in Appendectomy Patients: Comparison with Intramuscular Diclofenac
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 4
Abstract
Background: The aim of this study was to compare the efficacy and safety of diclofenac transdermal patch with intramuscular diclofenac injections in appendectomy patients Methods: Sixty participants of either sex scheduled for appendectomy were equally randomized into two groups. A transdermal diclofenac patch 100 mg was applied to the participants in the study group 3 hours prior to surgery. In the control group, 2 doses of 75 mg diclofenac sodium injections were given intramuscularly, first dose 2 hours after the surgery and second dose after 12 hours.In postoperative ward, assessment of intensity of pain was done by visual analogue scale (VAS) and verbal rating scale (VRS) for every six hours for a total duration of 24 hours. If a patient represented with VAS score >5 and VRS >2, necessitating urgent analgesia then in such situation there was a provision for rescue treatment, injection tramadol hydrochloride (50mg slow i.v. injection).Data were analysed using unpaired students t’ test. Results:Diclofenac patch provided effective analgesia for post appendectomy patients.Analgesia obtained with diclofenac patch was comparable with diclofenac injection and do not show any significant differences between the two. Also, no major adverse effect occurred due to application of diclofenac patch. Conclusion: Diclofenac patch can be considered as an alternative option for pain management of post appendectomy patients, as it also improves compliance due to once daily application. The dose of diclofenac diethylamine patch may be increased to 200 mg instead of 100 mg to control post-operative pain more effectively in patient of appendectomy
Authors and Affiliations
Grijesh Lakhan Paserkar
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