Efficacy and Tolerability of an Advance Face Night Cream in Reducing Facial Pigmentation and Wrinkles in Women
Journal Title: Journal of Dermatology Research - Year 2024, Vol 5, Issue 2
Abstract
Background: The efficacy and tolerance of an Advance Face Night Cream in reducing facial pigmentation and wrinkles in women was evaluated. Methods: This was a monocentric, single-group, comparative, open-label study involving healthy adult women with mild to-moderate wrinkles and at least one pigmented spot on the face. The Advance Face Night Cream was to be applied every night before bedtime along with sunscreen lotion (with sun protection factor [SPF] 50) during the day. Evaluations included clinical examination and grading of wrinkles in the crow’s feet area, nasolabial region, forehead and under the eyes. Skin lightening and skin hydration effects along with subjective efficacy were also evaluated. Results: Thirty-three women completed the study (mean age: 44.03±5.41 years). A significant decrease in the mean score of wrinkles in the crow’s feet area (7.5%; p=0.004) and on the forehead and under-eye region (12.5%; p=0.001) was noted at 45 days. The 3-dimensional imaging revealed a significant decrease in the mean overall size of wrinkles after 21 and 45 days (10.0% and 9.0%; p=0.002 and p=0.003, respectively) and the mean width of wrinkles (3.5% and 4.4%; p=0.007 and p=0.001, respectively). Comparable benefits in skin radiance, color and hydration were noted at both 21 and 45 days. Other benefits included improved skin moisture, reduced visible pigmentation and wrinkles and improved overall skin appearance. Conclusion: The topical application of Advance Face Night Cream and the appropriate usage of sunscreen lotion with SPF 50 led to a significant reduction in fine lines and the overall size and width of facial wrinkles in 3 and 6 weeks. The cream could significantly hydrate the skin, brighten the skin tone and lighten the skin color of the pigmented area in 3 weeks. No adverse events were reported by any participant during the study.
Authors and Affiliations
Rajiv Joshi, Dyotona Sen, Sanjay Choudhary
Keywords
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- EP ID EP741623
- DOI https://doi.org/10.46889/JDR.2024.5209
- Views 11
- Downloads 0
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