Efficacy and tolerability of calcium channel alpha-2-delta ligands in psychiatric disorders
Journal Title: Revista de Medicină Militară - Year 2017, Vol 0, Issue 2
Abstract
Matching drugs with anxiolytic properties- but without the potential of inducing dependence or abuse- with clinical manifestations of various affective disorders is a very important challenge for psychiatrists. Although the first line of pharmacologic treatment for anxiety disorders remains antidepressants with serotoninergic properties, calcium channel alpha-2-delta ligands are adjuvant agents which could be useful for augmenting antidepressant agents’ clinical effects. Unfortunately, calcium channel alpha-2-delta ligands efficacy and tolerability are not very well known, due to a lack of large scale, randomized, placebo-controlled trials focused on psychiatric disorders. Data regarding pregabalin and gabapentin pharmacology and clinical effects are reviewed and conclusions with pragmatically impact based on the discovered evidence are formulated accordingly.
Authors and Affiliations
Octavian Vasiliu, Daniel Vasile, Andrei Mangalagiu, Bogdan Petrescu, Corina Tudor, Daniela Ungureanu, C Candea
Keywords
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