Efficacy and Tolerability of Oral Triple Drug Combination (Voglibose, Glimepiride and Metformin) in the Management Type 2 Diabetes Mellitus
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 4
Abstract
The prevalence of diabetes is rapidly rising across the globe at an alarming rate. Despite the introduction of new agents efforts for better management of diabetes are disappointing and the control of blood glucose levels remains unsatisfactory. Material and method: The study was a post marketing surveillance (PMS) non-randomized, open, non-comparative, mono centric study. The triple drug fixed dose combination of Voglibose, Glimepiride and Metformin was administered to 20 Type 2 diabetic patients once daily for 4 months. Observation: Baseline value was recorded for glycated haemoglobin (HbA1c), fasting blood glucose and post prandial blood glucose level. There was a significant decrease in glycated haemoglobin value (9.07 ±0.346 to 6.51±0.129, p < 0.0001), fasting (181±10.2 mg/dl to 116±2.97 mg/ml P < 0.0001) and post prandial blood glucose level (239±11.2 mg/dl to 140±4.42 mg/dl P < 0.0004) after 4 months of treatment from the baseline. The combination was found to be effective in controlling both fasting and post prandial glucose level and was well tolerated. Conclusion: Fixed dose triple drug combination of voglibose plus metformin plus glimepiride significantly reduces the HbA1c value, fasting and post prandial blood glucose level with an excellent tolerability.
Authors and Affiliations
Hari K
Keywords
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