Efficacy and Tolerability of Oral Triple Drug Combination (Voglibose, Glimepiride and Metformin) in the Management Type 2 Diabetes Mellitus
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 4
Abstract
The prevalence of diabetes is rapidly rising across the globe at an alarming rate. Despite the introduction of new agents efforts for better management of diabetes are disappointing and the control of blood glucose levels remains unsatisfactory. Material and method: The study was a post marketing surveillance (PMS) non-randomized, open, non-comparative, mono centric study. The triple drug fixed dose combination of Voglibose, Glimepiride and Metformin was administered to 20 Type 2 diabetic patients once daily for 4 months. Observation: Baseline value was recorded for glycated haemoglobin (HbA1c), fasting blood glucose and post prandial blood glucose level. There was a significant decrease in glycated haemoglobin value (9.07 ±0.346 to 6.51±0.129, p < 0.0001), fasting (181±10.2 mg/dl to 116±2.97 mg/ml P < 0.0001) and post prandial blood glucose level (239±11.2 mg/dl to 140±4.42 mg/dl P < 0.0004) after 4 months of treatment from the baseline. The combination was found to be effective in controlling both fasting and post prandial glucose level and was well tolerated. Conclusion: Fixed dose triple drug combination of voglibose plus metformin plus glimepiride significantly reduces the HbA1c value, fasting and post prandial blood glucose level with an excellent tolerability.
Authors and Affiliations
Hari K
Keywords
Related Articles
- EP ID EP205716
- DOI -
- Views 118
- Downloads 0
Giant Cell Arteritis, a Headache that Blinds -Case report
Giant cell arteritis is a rare systemic granulomatousvasculitis affecting large- and medium-sized arteries.. Here we present a case of GCA with history of seizures, recurrent cerebrovascular accidents, ischemic heart dis...
Effectiveness of BLS & ACLS workshop on Cognitive, Affective and Psychomotor Skills at Rural Medical College, Loni
Background: The aim of our study was to know the effectiveness of Basic Life Support (BLS) &Advanced Cardiovascular Life Support (ACLS) Workshop conducted at Rural Medical College, Loni. Methods: Delegates interested for...
Profile of Low Vision Population Attending Retina Clinic, RIMS, Imphal Manipur
The main purpose of the study is to assess the cause of low vision over a period of 15 months. A retrospective study of 168 patients examined at Retina clinic, RIMS, Imphal over the period of 15 months was reviewed and i...
Awareness and Problems in Adolescent Girls Attending Adolescent Clinic in a Tertiary Hospital
Adolescence is a period of enormous physical and psychological change for young girls. Many adolescents with menstrual disturbances never present to their family doctor or gynaecologist. Embarrassment about discussing me...
Obstetric Outcome in Elderly Mothers aged 35 Years and above: Comparative Study
Introduction: Many women increasingly delay pregnancy and childbirth into their later decades of life because of different reasons, such as delay in marriage, educational and professional reasons. Advanced maternal age h...