Efficacy Appraisal of Some Antidiabetic Herbal Preparations Available in Bangladesh
Journal Title: Journal of Pharmaceutical Research International - Year 2015, Vol 8, Issue 3
Abstract
Antidiabetic Herbal Preparations (ADHP) are being used for the management of diabetes mellitus (DM) but their efficacy in controlling hyperglycemia is not scientifically evaluated. This study was undertaken to evaluate the antihyperglycemic potency of some selected antidiabetic HPs (herbal preparations) manufactured locally and readily available in Bangladesh. Six ADHPs were collected from herbal medicine shops in Dhaka city produced by five different local herbal pharmaceuticals companies. Acute and chronic responses of the selected ADHPs on glycemic status were determined by feeding test on streptozotocin induced type 2 diabetic model rats. Plasma glucose concentrations were measured at baseline and after oral administration of ADHPs. Acute responses were investigated after 30 and 60 minutes of oral glucose load when ADHPs were administered simultaneously or 30 minutes before oral glucose load. Chronic responses were investigated at 14 and 28 days after ADHPs administration in two different doses. Data were expressed as mean±SD. Statistical analysis within groups was done using paired‘t’- test. Comparison between groups was done using one-way ANOVA with post Hoc Bonferroni test. Among the six ADHPs tested, only ADHP-3 showed significant reduction of plasma glucose levels compared to control. It was effective at 30 (p<0.05) and 75 (p<0.01) minutes when ADHPs were administered simultaneously with oral glucose load. ADHP-3 was also effective at 60 and 105 minutes (p<0.01 at both time points) when ADHPs were administered 30 minutes before oral glucose load. In case of chronic responses evaluation, ADHP-3 at a dose of 200 mg/kg/day insignificantly reduced blood glucose levels compared to baseline (p=0.342) at 28 days but at a dose of 400 mg/kg/day significantly reduced blood glucose levels (p=0.040).
Authors and Affiliations
Md Ranzu Ahmed, Begum Rokeya, A. K. Azad Khan, Md Rausan Zamir, M. Abu Sayeed, M. Mosihuzzaman
Keywords
Related Articles
- EP ID EP344408
- DOI 10.9734/BJPR/2015/19870
- Views 56
- Downloads 0
Assessment of Haematological and Biochemical Effects of Kolaviron in Male Wistar Rats
This study determined the effects of kolaviron on the hematological and biochemical parameters of rats. The aim was to ascertain if its consumption has deleterious effects on these parameters. Forty adult male Wistar rat...
Application of Alumina-coated Carbon Nanotubes in Removal of Tetracycline from Aqueous Solution
The alumina-coated multi walled carbon nanotubes (Al2O3-coated MWCNTs) was used for removal of Tetracycline (TC) from aqueous solution in batch systems. The adsorption of TC occurred by studying the effects of adsorbent...
Anti-hemorrhoid Evaluation of Selected Medicinal Plants Used in Bali North-East Nigeria for the Treatment of Hemorrhoids (Pile)
A medicinal plant is any plant in which one or more of its organs contain substances that can be used for therapeutic purpose or which are precursors for the synthesis of useful drugs. In this research, six (6) selected...
Effect of Aqueous and Ethanol Leaf Extracts of Landolphia dulcis on Haematology and Histopathology of Swiss Albino Mice
Aims: To evaluate toxicological effect of aqueous and ethanol leaf extracts of Landolphia dulcis on haematology, liver and kidney physiological changes in mice. Study Design: In-vivo. Place and Duration of Study: Microb...
Effect of Root and Leaf Extracts of Tetracarpidium conophorum on Liver Enzyme Levels in Alloxan Induced Diabetic Rats
Aim: Tetracarpidium conophorum is a climbing shrub grown principally for its leaf, root, fruit and nut in Southern Nigeria and Western Cameroon. This study was conducted to assess the liver function status in alloxan- in...