Efficacy Laser Dermabrasion Followed by Topical 5- Fluorouracil in the Treatment of Stable Vitiligo
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 4
Abstract
Background: Vitiligo is one among the various dermatological conditions where medical treatment can offer only partial success. A combined approach in the form of skin ablation and topical 5 fluorouracil has given good results. Aim: In the present study, we are studying the effect of the use of laser skin ablation and application of 5 fluorouracil in treatment of patients with resistant vitiligo. Methods: This study included 30 adult patients with resistant vitiligo lesions. The patients were treated with laser skin ablation, followed by 5 fluorouracil application for 15 days. The cosmetic outcome was then evaluated after maximum period of 3 months. Results: Thirty patients were included (14 male and 16 females). Almost 40% of patients achieved excellent repigmentation (75-100%) after laser dermabrasion, followed by 5 fluorouracil application. Very good (50-75%) cosmetic results were achieved in 20% of patients, good improvement (25-50%) in 30% and poor improvement in (< 25%) only 10% of patients. Side-effects reported were transient hyperpigmentation in 3 (10%) patients; infection in 1(3.3%) patients, recurrence in 2(6.67%) patients while 24 (80%) patients did not report any untoward effects. Conclusion: We conclude our study by stating that laser skin ablation, followed by 5- fluorouracil application is an ideal treatment option for resistant vitiligo.
Authors and Affiliations
Dr. Mariam George
Keywords
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