Efficacy of adjunctive treatment with trimetazidine for fragmented QRS among patients with ischemic heart failure: a propensity score match analysis
Journal Title: The European Research Journal - Year 2019, Vol 5, Issue 2
Abstract
Objectives: Fragmented QRS (fQRS) is an indicator of nonhomogeneous ventricular activity caused by myocardial ischemia and fibrosis. The anti-ischemic agent trimetazidine (TMZ) added to pharmacological treatment appears to have positive effects on cardiac parameters of patients with ischemic heart failure. We aimed to investigate the relationship of fQRS with adjunctive TMZ therapy in ischemic HF patients. Methods: Four hundred eighty-nine consecutive ambulatory ischemic patients with heart failure eligible for our study were recruited for the study. A 12-lead electrocardiogram with standard chest and limb leads was used to evaluate the presence of fQRS. Further patients were divided into groups according to adjunctive TMZ treatment and fQRS presence. Confounding factors were adjusted by propensity score matching and multivariate logistic regression analysis. Results: One hundred ninety-seven (40.3%) patients had fQRS on their ECGs and 235 (48.1%) patients were on adjunctive treatment with trimetazidine. Compared to patients without fQRS, patients with fQRS had lower left ventricular ejection fraction (LVEF), higher NYHA classes and more frequent mineralocorticoid receptor antagonist and diuretic usage (p < 0.05). Add-on treatment with TMZ was independently associated with fQRS presence (OR, 0.45; (95% CI, 0.29-0.70); p < 0.0001). Conclusion: According to conventional therapy, adjunctive treatment with TMZ among ischemic heart failure patients can be associated with fQRS in 12-lead ECG independent of LVEF.
Authors and Affiliations
Selçuk Kanat, Barış Şensoy
Keywords
Related Articles
- EP ID EP502102
- DOI 10.18621/eurj.397369
- Views 106
- Downloads 0
The relationship between exercise dependence, cognitive style and personality characteristics in candidates participating in physical education and sports school special talent examination
Objectives: It has been suggested that there is a relationship between exercise dependence (ED), perfectionism, self-esteem and some personality characteristics.In the present study, the relations between ED and dysfunct...
The effectiveness of final intraoperative endoscopic control in conventional septoplasty
Objective. Septoplasty operation is a very common procedure and can be performed with endoscopic or conventional techniques. In some cases, preoperative nasal endoscopy can not be performed due to severe anterior deviati...
Class I pentalogy of Cantrell: a rare case report
Pentalogy of Cantrell is characterized by the presence of five major congenital defects involving the abdominal wall, pericardium, diaphragm, lower sternum and various cardiac abnormalities. This rare syndrome was descri...
Efficacy of preoperative trimetazidine for preventing myocardial injury in patients undergoing off-pump coronary artery bypass grafting
Objective. Off-pump coronary artery bypass grafting (CABG) with median sternotomy have been shown to be beneficial and associated with reduced myocardial injury. However, there is still a risk for ischemic myocardial inj...
Inlay butterfly cartilage tympanoplasty for large central perforations
Objective. The aim of this study is to evaluate the results of inlay butterfly tympanoplasty technique in large central tympanic membrane perforations. Methods. The files of the patients who underwent inlay butterfly car...