Efficacy of bretazenil against cortical epileptic afterdischarges increases during early ontogeny in rats.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 4
Abstract
The effect of a benzodiazepine partial agonist bretazenil on cortical epileptica fterdischarges was studied in 12-, 18- or 25-day-old rat pups with implanted electrodes. Afterdischarges were induced by low-frequency stimulation of sensorimotor area four times in each animal and bretazenil (0.1; 1; 5; 10; or 25 mg/kg) and/or solvent were administered intraperitoneally between the first and second stimulation. Bretazenil was able to decrease the duration of afterdischarges as well as intensity of clonic seizures accompanying these afterdischarges in all age groups in a dose-dependent manner. The efficacy of bretazenil was age-dependent: the most marked effect on duration of afterdischarges was observed in 25-day-old rats. It is in sharp contrast with our earlier data for full agonists clonazepam and midazolam demonstrating the strongest action in the youngest group.
Authors and Affiliations
Pavel Mares, Romana Slamberová
Keywords
Related Articles
- EP ID EP91182
- DOI -
- Views 101
- Downloads 0
Methamphetamine-induced neurotoxicity: the road to Parkinson's disease.
Studies have implicated methamphetamine exposure as a contributor to the development of Parkinson's disease. There is a significant degree of striatal dopamine depletion produced by methamphetamine, which makes the toxin...
Analgesia and serum assays of controlled-release dihydrocodeine and metabolites in cancer patients with pain.
Aim of the study was to assess dihydrocodeine (DHC) and metabolites concentrations and their correlations with DHC analgesia in cancer patients with pain. Thirty opioid-naive patients with nociceptive pain intensity asse...
Triptolide inhibits CCR5 expressed in synovial tissue of rat adjuvant-induced arthritis.
Triptolide has been clinically used to treat patients with rheumatoid arthritis, in which chemokine receptors play an important role in immune and inflammatory responses. To investigate the effect of triptolide on CCR5,...
Effect of BD 1047, a sigma(1) receptor antagonist, in the animal models predictive of antipsychotic activity.
The sigma receptors were first classified as a subtype of opioid receptors but later they were found to be a distinct pharmacological entity. Many preclinical and clinical data have indicated that sigma receptor ligands...
Mitochondria and vascular pathology.
Functional and structural changes in mitochondria are caused by the opening of the mitochondrial permeability transition pore (PTP) and by the mitochondrial generation of reactive oxygen species (ROS). These two processe...