EFFICACY OF CINITAPRIDE HYDROGEN TARTARATE IN GERD
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2014, Vol 1, Issue 8
Abstract
Gastroesophageal reflux disease (GERD) is a chronic symptom of mucosal damage caused by stomach acid coming up from the stomach into the esophagus. Pathophysiological evidences point towards disordered motility as the main cause of GERD rather than acid hyper secretion. Cinitapride hydrogen tartrate is a 5-HT2-receptor antagonist and 5-HT4- receptor agonist activity. OBJECTIVE: The present study was planned to assess the efficacy and safety of Cinitapride hydrogen tartarate 1 mg tablets in gastro oesophageal reflux disease. MATERIAL AND METHODS: 35 adult patients (›20 years old), both genders from the outpatient clinic in private practices with diagnosis of gastroesophageal reflux were enrolled. One patient left the study due to an adverse reaction. 34 patients were analyzed. All patients received cinitapride 1 mg three times a day for four weeks. Patients were also supplied antacid tablets, which could be taken as a rescue medication during the course of the study. RESULTS: Total 29 male patients and 6 female patients enrolled in the study. There was a significant reduction in the mean overall symptoms intensity score from 8.4±1.4 (range: 6-11) at baseline to 0.3±1.1 (range: 0-6) at the end of week 4. There was also a significant reduction in the mean intensity score of the individual symptoms i.e. feeling of gastric fullness, upper abdominal pain, anorexia, heartburn and nausea & vomiting from at the end of the study. All the patients enrolled into the study required antacid tablets as rescue medication initially but the mean number of antacid tablets consumed declined drastically from 7.1±3.4 (range: 2-14) at baseline to 0.5±1.4 (range: 0-6) at the end of the study. 29 of the 34 patients (85.3%) were rated to have an “excellent” efficacy to the study drug, 4 patients (11.8%) were rated to have a “good” efficacy and 1 patient (2.9%) was rated to have a “fair” efficacy to the study drug at the end of the study. 4 patients developed adverse events during the course of the study –diarrhea, drowsiness, increased passage of flatus and lethargy. CONCLUSION: Cinitapride is effective and well tolerated in the treatment of adult patients with gastroesophageal reflux.
Authors and Affiliations
Puneet Rijhwani, Agarwal C. M. , Mohammed Shoaib, Prerna Upadhyaya, Pradeep Agarwal
DIAGNOSTIC UTILITY OF CELL BLOCK METHOD IN PLEURAL FLUID CYTOLOGY
The cytological study of body fluids is one of the oldest applications of cytological techniques. A variety of conditions cause pleural effusion. Specific diagnosis is a major challenge and the possibility of malignant i...
ANAESTHETIC MANAGEMENT OF NMDA RECEPTOR ENCEPHALITIS IN A 19-YEAR-OLD PATIENT WITH OVARIAN DERMOID POSTED FOR CYSTECTOMY- A RARE CASE REPORT
PRESENTATION OF CASE A 19-year-old female patient presented with auditory hallucinations along with unusual phobias and abnormal behaviour for 1 year. DIFFERENTIAL DIAGNOSIS The differential diagnosis included psychosis,...
INTRAMUSCULAR HYDATID CYST OF PARASPINAL MUSCLE: A RARE LOCATION
Hydatid disease has a worldwide distribution and causes health problems in endemic countries. The parasite has a "dog-sheep" cycle with man as an intermediate accidental host. When humans ingest the eggs of the tapeworm,...
CARDIOMETABOLIC PROFILE IN PATIENTS OF ACUTE CORONARY SYNDROME
BACKGROUND The aim is to study cardiometabolic profile in patients with acute coronary syndrome (ACS) with reference to metabolic syndrome (MS). MATERIALS AND METHODS This study was carried out in Acharya Vinoba Bhave Ru...
ANALYTICAL STUDY OF ESSENTIAL INFANTILE ESOTROPIA AND ITS MANAGEMENT
BACKGROUND Essential Infantile Esotropia (EIE) is the most common type of strabismus. About 0.1% of the newborn are found to have esotropia.1 Though present since birth, it becomes manifest and remains constant around si...