Efficacy of Combination Therapy of Rosuvastatin and Ezetimibe vs Rosuvastatin Monotherapy on Lipid Profile of Patients with Coronary Artery Disease
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 12
Abstract
Introduction: Dyslipidaemia is one of the most important modifiable risk factor for the development of Coronary Artery Disease (CAD). Although, statins are established as first line lipid-lowering therapy, they may not be able to achieve treatment goals in significant number of patients. Combination therapy of statin with a non-statin drug like Ezetimibe is a therapeutic option. Aim: To compare the efficacy and safety of Rosuvastatin/ Ezetimibe combination therapy vs Rosuvastatin alone on the lipid profile of patients with CAD in Northern India. Materials and Methods: This randomized prospective study was conducted on 80 patients of CAD presenting to Department of Medicine, Government Medical College, Patiala, Punjab, India. The patients were randomly divided into age and sex matched two groups of 40 each. After baseline investigations and lifestyle modifications, Group I was started on rosuvastatin 10 mg once daily, while Group II was started on rosuvastatin 10 mg+ezetimibe 10 mg daily. The fasting serum lipid profile was repeated initially after 12 weeks and then after 24 weeks. The two groups were observed for side effects which were noted. Results: The combination therapy of rosuvastatin and ezetimibe resulted in significantly higher change in all lipid parameters (LDL-C, TC, TG, HDL-C) as compared to treatment with rosuvastatin alone. There was no difference in the adverse effects seen after treatment in the two groups. Conclusion: Our study showed that combination therapy of ezetimibe with rosuvastatin can be used as an effective and safe therapy in high risk patients of CAD, especially in patients in whom statin monotherapy is not able to achieve the target lipid levels.
Authors and Affiliations
Sandeep Joshi, Ruby Sharma, Harbir Kaur Rao, Udit Narang, Nitin Gupta
Keywords
Related Articles
- EP ID EP367765
- DOI 10.7860/JCDR/2017/30458.11004
- Views 51
- Downloads 0
Serum Ferritin, Iron Deficiency Anaemia and Haemoglobin A1c in Non-diabetic Pregnant Women
ABSTRACT Introduction: The association between Iron Deficiency Anaemia (IDA) and Haemoglobin A1c (HbA1c) levels is not yet fully investigated. It is suggested that iron-deficiency anaemia may increase concentrations of H...
Osteochondroma in Jordanian Patients: Clinical Manifestations and Management
ABSTRACT Introduction: Osteochondroma is the most common benign bone tumour which can be solitary or multiple. Although usually asymptomatic, its associated deformities and secondary malignant transformation potential mi...
Radiation Dose Reduction and Cancer Risk Estimation Associated with Upper Limbs Radiographic Examination by using Optimal Projections: A Phantom Study
ABSTRACT Introduction: Ionising radiation used during medical imaging examinations should be monitored carefully to reduce the radiation harm and biological effects. In radiography, As Low As Reasonably Achievable (ALARA...
Intraoperative Rupture of Hydatid Cyst Membrane: A Flexible Rhino-laryngoscope Innovation to the Rescue
ABSTRACT The present case report describes a catastrophe avoided during operative removal of hydatid cyst located in the lower lobe of left lung. The intrabronchial hydatid cyst membranes ruptured intraoperatively and w...
Analysis of Risk Factors and Outcome of Renal Failure in Benign Prostatic Hyperplasia
ABSTRACT Introduction: Benign Prostatic Hyperplasia (BPH) is one of the most common diseases of aging men, affecting 50% by 60 years of age and increasing to 90% by ninth decade of life. A small percentage of men with ob...