EFFICACY OF KETAMINE GARGLE FOR ATTENUATING POSTOPERATIVE SORE THROAT IN PATIENTS UNDERGOING GENERAL ANAESTHESIA WITH ENDOTRACHEAL INTUBATION
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 81
Abstract
BACKGROUND Postoperative sore throat is ranked by American Society of Anesthesiologists as eighth most important problem of current clinical anaesthesiology. This study is to evaluate whether preoperative gargling with ketamine reduce postoperative sore throat after endotracheal intubation when compared with gargling with saline. MATERIALS AND METHODS 130 patients of either sex in the age group 20 - 60 years scheduled for elective surgery under general anaesthesia with endotracheal intubation were included in the study. The duration of surgeries was taken as less than or equal to 3 hours. Patients were asked to gargle with preparation for 30 seconds. Anaesthesia was induced 5 minutes later. Patients were interviewed by a blinded investigator at 4, 8, 24 hours after the procedure for postoperative sore throat. Postoperative sore throat was graded on a four point scale. Group 1 will receive preservative free ketamine 50 mg in 29 mL 0.9% saline. Group 2 will receive 30 mL 0.9% saline. RESULTS The groups were comparable with respect to age, sex, weight, height, ASA grading, type of surgery and duration of surgery. There was no statistically significant difference in comparison of pulse rate or blood pressure between the two groups at specific time intervals. The overall incidence of sore throat in control group and study group at 4 hrs., 8 hrs. and 24 hrs. intervals was analysed with Mann-Whitney U test, which showed p value of less than 0.05 and difference was statistically significant. Incidence of severe sore throat was significantly higher in control group than study group. There were no adverse reactions noted in ketamine group. CONCLUSION In conclusion, gargling with ketamine for 30 seconds five minutes prior to induction reduces postoperative sore throat.
Authors and Affiliations
John Varghese Thoppil, Sheeila Rani Imanual
Keywords
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- EP ID EP275355
- DOI 10.14260/jemds/2017/1238
- Views 66
- Downloads 0
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