EFFICACY OF MITOMYCIN - C 0.02% VERSUS CONJUNCTIVAL AUTOGRAFT IN PREVENTING RECURRENCE FOLLOWING PTERYGIUM EXCISION: A COMPARATIVE STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2014, Vol 3, Issue 13
Abstract
[b]BACKGROUND[/b]: Pterygium is an elevated, triangular, fibrovascular encroachment of bulbar conjunctiva on to the cornea. Prevalence of pterygium is high in the tropical belt of the world, especially in India where hot, sunny and dusty weather favors its growth. The recurrence rate of traditional Bare Sclera technique ranges from 24% - 89%.To tackle the problem of recurrence, many adjuvant therapies have been tried among which Intraoperative application of Mitomycin-C (MMC) and Conjunctival autograft (CAG) have stood the test of time. Hence this study is undertaken to compare the efficacy of these two standard techniques in preventing recurrence following excision of pterygium. [b]AIMS:[/b] To compare the effectiveness of 0.02% Intraoperative Mitomycin-C application for two minutes versus Conjunctival Autografting in preventing recurrence following excision of pterygium. [b]METHODS AND MATERIALS[/b]: The present prospective randomized clinical trial was conducted over a period of two years. In the study, 80 eyes of 80 patients were included after detailed preoperative evaluation. They were randomized into two groups to receive either conjunctival autograft or Intraoperative application of 0.02% Mitomycin C for 2 minutes, following excision of pterygium. 80 cases completed the study with follow up of one year. [b]STATISTICAL [/b] [b]METHOD:[/b] prospective clinical randomized study [b]RESULTS:[/b] Of the 80 cases, there were 7 recurrences, out of which 3 cases belonged to CAG Group (7.5%) and 4 cases were from MMC Group (10%). This difference was not statistically significant (p>0.05). 75% of the recurrent cases were Progressive Pterygium and 25% were regressive. The average time of recurrence was 6 months .The average age of recurrence was 41 years. The overall rate of complication was 11.25%%, with the rate in CAG Group being 10% and 12.5% in MMC Group. The difference is not statistically significant (p>0.05). [b]CONCLUSION: [/b]From our study, we conclude that both Conjunctival Autograft technique and Intraoperative application of 0.02% Mitomycin C for two minutes is equally effective in preventing or reducing recurrence following excision of Pterygium. Both the methods appear to be safe and acceptable in pterygium surgery
Authors and Affiliations
Ambika Patil, Sanjeev Patil
Keywords
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- EP ID EP122676
- DOI 10.14260/jemds/2014/2310
- Views 76
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