Abstract

Back Ground & Objectives: Physiologic effects of prolonged carbon dioxide insufflation have a major impact on cardiopulmonary function. Atenolol, has been extensively studied but only few attempts have been made to evaluate it in laparoscopic surgeries. Study was aimed to evaluate the clinical effects of oral Atenolol premedication in attenuating the hemodynamic changes during the period of pneumoperitoneum in patients undergoing laparoscopic cholecystectomy. Methods: Prospective, randomized, double blinded study was conducted, on fifty ASA I & II patients, 30 to 60 years, for elective laparoscopic cholecystectomy. Group I (Atenolol): Atenolol tablet. Group II (Placebo): Vitamin C tablet. Premedication, preoxygenation, induction intubation and maintenance was standardised for both groups. Monitoring data was recorded every 2 minutes for the first 30 minutes of pneumoperitoneum and thereafter every 5 minutes for the rest of the operation. Results: Comparisons of values bring out the difference in the hemodynamics between the two groups, with a statically significant lower level in Atenolol group. Conclusions: Atenolol 50mg premedication elective laparoscopic cholecystectomy can bring in a stable hemodynamics compared to placebo

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