Efficacy of Phenytoin Mucoadhesive Tablet versus Mouthwash on Chemotherapy-Induced Oral Mucositis: A Randomized Clinical Trial
Journal Title: Middle East Journal of Cancer - Year 2019, Vol 10, Issue 4
Abstract
Background: Oral mucositis is one of the painful, debilitating and common complications in the patients under chemotherapy for which no certain and effective treatment has not been considered. The aim of this pilot study was to evaluate the efficacy of phenytoin mucoadhesive tablets on treating oral mucositis compared with phenytoin mouthwash. Methods: In this clinical trial, after preparation and in vitro characterization of phenytoin mucoadhesive tablets, 27 patients were enrolled from oncology department of Nemazee Hospital, Shiraz, Iran. 21 patients with oral mucositis, who had the inclusion criteria due to chemotherapy, were divided into two groups of A (11 patients received phenytoin mouthwash 0.5%) and B (10 patients received phenytoin mucoadhesive tablet). Severity of oral mucositis (WHO grading), oral pain Visual Analogue Scale and the extension of lesions (number of involved sites) were assessed on three intervals (at the beginning and one or two weeks after beginning of the study). Results: In the first visit, there was no significant statistical difference between the two groups regarding mean age, mucositis severity and visual analogue scale. However, on first and second weeks after beginning of the study, mucositis severity, extension of lesion and visual analogue scale in both groups were significantly lower than onset of the treatment; however, no significant difference between the two groups was observed. Conclusions: Phenytoin mouthwash and mucoadhesive tablets used for oral mucositis care in patients after chemotherapy showed significant improvement in the lesions. Patients were more satisfied with mouthwash and all the patients in this group were free of lesion after two weeks.
Authors and Affiliations
Fahimeh Rezazadeh, Soleiman Mohammadi-Samani, Fatemeh Talei, Mani Ramzi, Hajar Ashrafi, Zahra Emami
Keywords
Related Articles
- EP ID EP638934
- DOI 10.30476/mejc.2019.78656.
- Views 65
- Downloads 0
Environmental Risk Factors Associated with Sporadic Colorectal Cancer in Isfahan, Iran
Background: Records from the cancer registry system of Iran indicate that colorectal cancer is the third most common cancer in Iranian men and fourth most common among Iranian women. In this study we have investigated th...
Low-grade Myxofibrosarcoma in the Mandible: A Rare Case Report
Myxofibrosarcoma is a malignant neoplasm of connective tissue origin commonly found in the extremities. It is very rare in the head and neck regions. Only 25 cases of myxofibrosarcoma have been reported in the head and n...
Predictive Markers for Hepatocellular Carcinoma Development in Patients with Chronic Hepatitis C Virus Genotype4a
Background: Egypt has the highest prevalence of hepatitis C virus worldwide. Monitoring hepatitis C-infected patients for hepatocellular carcinoma development is an important clinical issue to diagnose these patients dur...
FOXP3 Genetic Variation at Position -2383 C/T (rs3761549) in Patients with Breast Cancer
Background:We investigated the possibility of an association between the C-2383T polymorphism (rs3761549) in the promoter region of the FOXP3 gene with breast cancer. Methods: The study groups consisted of 250 women diag...
Evaluation of Breast Cancer Risk in Relation to Occupation
Background: Breast cancer is the most common cancer in females. At present, evidence exists to support an association of breast cancer with several risk factors such as occupational risk factors. The aim of this study is...