Efficacy of Recombinant Interferon-α-2b Application in Children with Virus-Induced Bronchial Asthma Phenotype
Journal Title: Здоров`я дитини - Year 2013, Vol 6, Issue 49
Abstract
The paper presents the results of the study of the efficacy of recombinant interferon α-2b use in children with bronchial asthma, who often suffer from acute respiratory viral infection (ARVI). It is established that under the influence of recombinant interferon-α-2b use for prolonged scheme, the content of INF-γ increases, the concentration of IgE decreases, with the tendency to normalization of the oxidant-antioxidant status. The clinical criteria of recombinant interferon-α-2b efficcacy are 2.4-fold decrease in ARVI incidence, 3.3-fold reduction in the frequency of bronchial asthma against ARVI, which has a positive effect on the clinical course of bronchial asthma. The period of remission in patients increased up to 4–6 months, duration of seizure period decreased.
Authors and Affiliations
O. V. Fofanova
Keywords
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