Efficacy of Selective Estrogen Receptor Modulators in the Management of Abnormal Uterine Bleeding In Women of Early Reproductive Age Group
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 10
Abstract
Study was aimed to compare the therapeutic efficacy of SERMs (ormeloxifene) to Norethisterone in the medical management of Abnormal Uterine Bleeding (AUB).It was Prospective, comparative, interventional randomized study. A total of 60 women who attended Outpatient Gynaecology Department ,Guwahati with complain of AUB in reproductive age group were randomly allocated to 2 equal groups, Group-O, which received 60mg ormeloxifene twice weekly for 3 months then once weekly for next 3 months and Group N which received 5 mg Norethisterone twice daily for 21 days for 6 months. The reduction in mean PBAC score with ormeloxifene (176.8 to 29.13) was significantly more than that seen with Norethisterone (179.73 to 86.87) after 6 months of therapy (p<0.0035). The increase in haemoglobin level and reduction in endometrial thickness was significantly more with ormeloxifene than Norethisterone (8.8gm/dl to 10.1gm/dl vs 8.7gm/dl to 9.2gm/dl( p value 0.0031) ,8.9 mm to 2.4mm vs 7.8mm to 5.9mm (p value0.0035) respectively. No major side effects were reported in any group. Ormeloxifene was found to be more effective than Norethisterone in reducing PBAC score and endometrial thickness. Keywords: Abnormal uterine bleeding, early reproductive age, Ormeloxifene, Norethisterone, Pictorial blood loss assessment chart score (PBAC).
Authors and Affiliations
Dr. R. K. Talukdar, Dr D. J. Gharphalia, Dr. Ankita Mani
Keywords
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